2. Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related
  3. DNA Alkylator/Crosslinker ADC Payload
  4. seco-CBI dimer

seco-CBI dimer 是一种 DNA 烷化剂，是 Duocarmycin 的前药，可作为有效载荷，合成抗体-药物偶联物 (ADC)。seco-CBI dimer 结合于 DNA 富含 A-T 区域的小沟，使腺嘌呤残基的 N3 位烷基化，并诱导 DNA 链断裂。seco-CBI dimer 可用于非霍奇金淋巴瘤的研究。

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seco-CBI dimer

seco-CBI dimer Chemical Structure

CAS No. : 2592397-70-9

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seco-CBI dimer 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

seco-CBI dimer is a DNA alkylating agent and a prodrug of Duocarmycin, which can serve as a payload for synthesizing antibody-drug conjugates (ADCs). seco-CBI dimer binds to the minor groove of A-T-rich regions in DNA, alkylates the N3 position of adenine residues, and induces DNA strand breaks. seco-CBI dimer can be used in the research of non-Hodgkin's lymphoma[1].

体外研究
(In Vitro)

基于 seco-CBI dimer 的 ADC 可在体外强效抑制 CD22 阳性淋巴瘤细胞的生长，其 IC50 值为 10-80 pM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

seco-CBI dimer 相关抗体:
分子量

735.65

Formula

C41H36Cl2N4O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

seco-CBI dimer 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

seco-CBI dimer2592397-70-9DNA Alkylator/CrosslinkerADC PayloadADC Cytotoxinα1-microglobulincynomolgus monkeysA-T-rich regionslymphoma cellsadenine residuesDNA minor groovelymphoma xenograft modelspinatuzumab-vedotin-resistant tumorsnon-hodgkin lymphomaCD22-positive lymphoma cellInhibitorinhibitorinhibit

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