2. Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related
  3. DNA Alkylator/Crosslinker ADC Payload
  4. seco-CBI-PBD dimer

seco-CBI-PBD dimer 是一种 CBI-PBD 异源二聚体和 DNA 小沟交联剂。seco-CBI-PBD dimer 对人类肿瘤细胞具有亚 pM 至低 nM 的细胞毒性，且对 P-糖蛋白介导的耐药性敏感性较低，可用于 ADC 有效载荷。seco-CBI-PBD dimer 可用于子宫癌、乳腺癌、非小细胞肺癌等研究。

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seco-CBI-PBD dimer

seco-CBI-PBD dimer Chemical Structure

CAS No. : 550356-40-6

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seco-CBI-PBD dimer 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

seco-CBI-PBD dimer is a CBI-PBD heterodimer and a minor groove DNA crosslinker. seco-CBI-PBD dimer exhibits cytotoxicity against human tumor cells at sub-pM to low nM levels, shows low sensitivity to P-glycoprotein-mediated drug resistance, and can serve as an ADC payload. seco-CBI-PBD dimer can be used in studies of uterine cancer, breast cancer, non-small cell lung cancer, etc.[1]

体外研究
(In Vitro)

Seco-CBI-PBD dimer (Compound 5) (0-100 nM; 96 h) 可强效抑制 MES-SA、MES-SA/Dx5、BJAB、KPL-4、HCC1569 X2、T-47D、HCC1937、NCI-H1781 和 SW 900 人肿瘤细胞系的增殖，其 IC50 值范围为 0.0098 nM 至 0.13 nM；在高浓度下可完全抑制细胞增殖，且对 P-糖蛋白介导的耐药性敏感性较低[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

seco-CBI-PBD dimer 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: MES-SA, MES-SA/Dx5, BJAB, KPL-4, HCC1569 X2, T-47D, HCC1937, NCI-H1781, SW 900
Concentration: 0, 0.01, 0.1, 1, 10 and 100 nM
Incubation Time: 96 h
Result: Exhibited potent cytotoxicity with IC50 values as follows: 0.033 nM (MES-SA), 0.11 nM (MES-SA/Dx5), 0.011 nM (BJAB), 0.036 nM (KPL-4), 0.13 nM (HCC1569 X2), 0.016 nM (T-47D), 0.11 nM (HCC1937), 0.0098 nM (NCI-H1781), 0.051 nM (SW 900).
Completely inhibited proliferation of all cell lines tested at sufficiently high concentrations.
Showed low sensitivity to P-glycoprotein overexpression, with an IC50 ratio of 3.3 between MES-SA/Dx5 (high P-glycoprotein) and MES-SA (P-glycoprotein-negative).
分子量

576.08

Formula

C32H34ClN3O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

seco-CBI-PBD dimer 相关分类

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Keywords:

seco-CBI-PBD dimer550356-40-6DNA Alkylator/CrosslinkerADC PayloadADC Cytotoxinuterine cancerhuman tumour cellscytotoxinMES-SAnon-small cell lung cancerP-glycoprotein-mediated resistancebreast cancerDNA minor groove cross-linking agentMES-SA/Dx5B-cell cancerInhibitorinhibitorinhibit

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