2. MAPK/ERK Pathway GPCR/G Protein
  3. SOS1 Ras
  4. SOS1/KRAS-IN-2

SOS1/KRAS-IN-2 (Compound 20) 是一种 SOS1::KRASG12C 蛋白-蛋白相互作用抑制剂，IC50 为 4.11 nM。SOS1/KRAS-IN-2 可阻断 SOS1 与 KRASG12C 之间的相互作用。SOS1/KRAS-IN-2 可诱导细胞凋亡。SOS1/KRAS-IN-2 对结直肠癌和舌鳞状细胞癌表现出抗癌活性。

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SOS1/KRAS-IN-2

SOS1/KRAS-IN-2 Chemical Structure

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SOS1/KRAS-IN-2 相关抗体

Top Publications Citing Use of Products

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K-Ras H-Ras N-Ras Ras

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SOS1/KRAS-IN-2 (Compound 20) is a SOS1::KRASG12C protein-protein interaction inhibitor with a IC50 of 4.11 nM. SOS1/KRAS-IN-2 blocks the interaction between SOS1 and KRASG12C. SOS1/KRAS-IN-2 induces cell apoptosis. SOS1/KRAS-IN-2 exhibits anticancer activity against colorectal cancer and tongue squamous cell carcinoma[1].

IC50 & Target[1]

KRAS G12C-SOS1

4.11 nM (IC50)

体外研究
(In Vitro)

SOS1/KRAS-IN-2 可强效抑制 SOS1::KRASG12C 蛋白-蛋白相互作用，其 IC50 为 4.11 ± 0.19 nM[1]。
SOS1/KRAS-IN-2 (7 天) 可抑制 DLD-1 结直肠癌细胞增殖，其 IC50 为 134.4 ± 5.12 nM[1]。
SOS1/KRAS-IN-2 (100 μM) 可将舌鳞状细胞癌细胞系 CAL-27 的增殖抑制 84.41 ± 10.36%[1]。
SOS1/KRAS-IN-2 (100-400 nM; 24 h) 可在 DLD-1 结直肠癌细胞中诱导剂量依赖性细胞凋亡[1]。
SOS1/KRAS-IN-2 (100-400 nM; 24 h) 可在 DLD-1 结直肠癌细胞中诱导呈剂量依赖性的 G0/G1 细胞周期阻滞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SOS1/KRAS-IN-2 相关抗体:

Apoptosis Analysis[1]

Cell Line: DLD-1 colorectal cancer cells
Concentration: 100-400 nM
Incubation Time: 24 h
Result: Induced apoptosis in a dose-dependent manner, with the percentage of apoptotic cells increasing progressively at higher concentrations.
Detected apoptosis starting at 100 nM.
分子量

441.45

Formula

C23H22F3N5O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SOS1/KRAS-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SOS1/KRAS-IN-2SOS1RasRas/Rac guanine nucleotide exchange factor 1G0/G1 cell-cycle arresthuman tongue squamous carcinoma cellcolorectal cancerCAL-27DLD-1apoptosisSOS1::KRASG12CKRASG12Ccolorectal cancer cellsInhibitorinhibitorinhibit

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