2. Others
  3. Fluorescent Dye
  4. TiY

TiY 是一种荧光探针，可特异性标记肿瘤起始细胞 (TIC)，不标记分化型肿瘤细胞与正常细胞。TiY 可结合波形蛋白 (vimentin)，一种上皮间质转化 (EMT) 标志物，且对四聚体波形蛋白的亲和力高于单体波形蛋白。TiY 有助于可视化富集具有功能活性的肿瘤起始细胞，同时可抑制肿瘤起始细胞，且对非肿瘤起始细胞的毒性较低。

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TiY

TiY Chemical Structure

CAS No. : 2417649-29-5

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TiY 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TiY is a fluorescent probe that selectively stains tumor initiating cells (TIC) over differentiated tumor cells or normal cells. TiY binds to vimentin, a marker for epithelial-to-mesenchymal transition (EMT) and has higher affinity for tetramerized vimentin than for monomeric vimentin. TiY facilitates visualization and enrichment of functionally active tumor initiating cells, and inhibits tumor initiating cells with low toxicity to non-tumor initiating cells[1].

体外研究
(In Vitro)

TiY 可选择性染色非小细胞肺癌肿瘤起始细胞 (TS32, TS10)，而非分化型非肿瘤起始细胞 (32A) 及正常肺上皮细胞 (LuEpi)，并能从这些细胞群中富集具有功能活性、肿瘤球形成能力强的肿瘤起始细胞[1]。
TiY 对四聚化波形蛋白的亲和力高于对单体波形蛋白的亲和力[1]。
TiY (0.1-27 μM) 对人肺癌起始细胞 (TS32、TS10) 表现出选择性抗肿瘤起始细胞活性，对分化的非起始细胞 (32A) 和正常肺上皮细胞 (LuEpi) 毒性较低，在 9 和 27 μM 时可显著降低细胞存活率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TiY 相关抗体:
分子量

541.87

Formula

C29H35BClF2N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TiY 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TiY2417649-29-5Fluorescent DyeLuEpiTS10patient-derived tumorsvimentintumor spherenon-small cell lung cancernormal lung epithelial cells32Atumor initiating cellsTS32Inhibitorinhibitorinhibit

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HY-D3177
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