1. Anti-infection
  2. SARS-CoV
  3. TPG-20A

TPG-20A 是一种 SARS-CoV-2 主蛋白酶抑制剂,其 IC50 值为 27.8 nM。TPG-20A 还能抑制 MERS-CoV 主蛋白酶。TPG-20A 可用于感染相关研究,如 SARS-CoV-2 研究。

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TPG-20A

TPG-20A Chemical Structure

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TPG-20A is a SARS-CoV-2 main protease inhibitor with an IC50 of 27.8 nM. TPG-20A also inhibits MERS-CoV main protease. TPG-20A can be used for the research of infection, such as SARS-CoV-2[1].

IC50 & Target[1]

SARS-CoV-2

27.8 nM (IC50)

体外研究
(In Vitro)

TPG-20A (Compound 20a) 对暴露于 SARS-CoV-2WK-521 的 VeroE6 细胞或暴露于 SARS-CoV-2BQ.1.1 的 HeLaACE2-TMPRSS2 细胞的 EC50 值分别为 3.9 μM 和 0.46 μM[1]
TPG-20A 对 VeroE6 细胞和 HeLaACE2-TMPRSS2 细胞的 CC50 值均大于 100 μM[1]
TPG-20A 对 SARS-CoV-2 Mpro和 MERS-CoV Mpro 的 IC50 值分别为 7.1 nM 和 42.9 nM[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

536.41

Formula

C24H27Cl2N5O5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

TPG-20A 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
TPG-20A
目录号:
HY-178188
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