2. Apoptosis
  3. TNF Receptor
  4. Trichodimerol

Trichodimerol (BMS-182123) 是一种 TNF-α 启动子抑制剂，可抑制脂多糖诱导的细胞因子分泌的活性。Trichodimerol 可抑制脂多糖诱导的 TNF-α 启动子活性，降低稳态 TNF-α mRNA 表达，且不会改变 TNF-α mRNA 的稳定性。Trichodimerol 可抑制小鼠和人免疫细胞中脂多糖诱导的 TNF-α 分泌。Trichodimerol 可在体外将脂多糖诱导的 IL-1β 分泌降低 25%-50%。Trichodimerol 在有效浓度下不会改变总蛋白质合成或组成型溶菌酶分泌。Trichodimerol 可用于感染性休克的研究。

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Trichodimerol

Trichodimerol Chemical Structure

CAS No. : 145174-90-9

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Trichodimerol 相关抗体

Top Publications Citing Use of Products

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Trichodimerol (BMS-182123) is a TNF-α promoter inhibitor that inhibits the activity of lipopolysaccharide-induced cytokine secretion. Trichodimerol inhibits lipopolysaccharide-induced TNF-α promoter activity, reduces steady-state TNF-α mRNA expression, and does not alter the stability of TNF-α mRNA. Trichodimerol inhibits lipopolysaccharide-induced TNF-α secretion in murine and human immune cells. Trichodimerol reduces lipopolysaccharide-induced IL-1β secretion by 25%-50% in vitro. Trichodimerol does not alter total protein synthesis or constitutive lysozyme secretion at effective concentrations. Trichodimerol can be used for the research of septic shock[1].

体外研究
(In Vitro)

Trichodimerol (BMS-182123) 可浓度依赖性地抑制脂多糖 (LPS) 诱导的小鼠 RAW 264.7 巨噬细胞中 TNF-α 的产生，IC50 为 600 ng/mL[1]。
Trichodimerol (0.1-4.0 μg/mL; 2 h) 可浓度依赖性地抑制 LPS 诱导人外周血单核细胞产生 TNF-α，2 h 的 IC50 为 4.0 μg/mL[1]。
Trichodimerol 可浓度依赖性地抑制转染后的小鼠 RAW 巨噬细胞中 LPS 诱导的人 TNF-α 启动子活性，18-20 h 的 IC50 为 200 ng/mL[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Trichodimerol 相关抗体:

Real Time qPCR[1]

Cell Line: Murine macrophages
Concentration: 2 μg/mL
Incubation Time: 4 h
Result: Significantly reduced LPS-induced steady-state TNF-α mRNA expression in murine macrophages without altering mRNA stability.
分子量

496.55

Formula

C28H32O8
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Trichodimerol 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trichodimerol145174-90-9BMS-182123BMS182123BMS 182123TNF ReceptorTumor Necrosis Factor ReceptorTNFRinterleukin-1βhuman peripheral blood monocyteslysozymeTNF-α promoterlipopolysaccharidemurine immune cellsRAW 264.7 macrophagesTNF-α mRNAhuman immune cellsseptic shockInhibitorinhibitorinhibit

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