2. GPCR/G Protein
  3. Leukotriene Receptor
  4. U-19052

U-19052 是一种选择性竞争性 peptidoleukotriene D/E 受体拮抗剂。U-19052 作为可逆性拮抗剂，不影响非白三烯激动剂的反应。U-19052 在豚鼠气管回肠条中无激动剂活性，也不会诱导收缩反应。U-19052 是通过修饰白三烯化学结构开发的白三烯拮抗剂。U-19052 可用于过敏性哮喘和超敏反应疾病的研究。

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U-19052

U-19052 Chemical Structure

CAS No. : 112682-32-3

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U-19052 相关抗体

Top Publications Citing Use of Products

查看 Leukotriene Receptor 亚型特异性产品:

查看所有亚型
LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

U-19052 is a selective competitive peptidoleukotriene D/E receptor antagonist. U-19052 acts as a reversible antagonist that not affecting responses to non-leukotriene agonists. U-19052 does not exhibit agonist activity or induce contraction in guinea pig tracheal or ileal strips. U-19052 is a leukotriene antagonist developed by modifying leukotriene chemical structure. U-19052 can be used for the research of allergic asthma and hypersensitivity diseases[1][2].

体外研究
(In Vitro)

U-19052 (10 μM；30 分钟) 是豚鼠气管条上肽白三烯受体的选择性竞争性拮抗剂，其针对 LTD4 的 pKB 为 6.43，针对 LTE4 的 pKB 为 5.80，针对 LTC4 的 pKB 为 5.54[1]。
U-19052 (10 μM；10 分钟) 可抑制 LTE4 诱导的豚鼠气管条收缩，且无激动剂活性[1]。
U-19052 (10 μM；60 分钟) 可作为豚鼠回肠段上肽白三烯受体的竞争性拮抗剂，对 LTD4 的 pKB 为 7.25，对 LTE4 的 pKB 为 7.17[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

U-19052 相关抗体:
分子量

542.73

Formula

C31H42O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

U-19052 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

U-19052112682-32-3U19052U 19052Leukotriene Receptorhypersensitivity diseasesguinea pig ileal stripspeptidoleukotriene receptorsguinea pig tracheal stripsallergic asthmapeptidoleukotriene D/E receptorleukotriene
Inhibitorinhibitorinhibit

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产品名称：
U-19052
目录号：
HY-182515
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