2. GPCR/G Protein
  3. Platelet-activating Factor Receptor (PAFR)
  4. UR-11353

UR-11353 是一种具有长效活性的选择性血小板活化因子 (PAF) 拮抗剂。UR-11353 可抑制兔富血小板血浆中 PAF 诱导的血小板聚集。UR-11353 可抑制正常血压大鼠中 PAF 诱导的低血压。UR-11353 可保护小鼠免受 PAF 诱导的死亡。

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UR-11353

UR-11353 Chemical Structure

CAS No. : 138060-13-6

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UR-11353 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UR-11353 is a selective platelet activating factor (PAF) antagonist with long-lasting activity. UR-11353 inhibits PAF-induced platelet aggregation in rabbit platelet-rich plasma. UR-11353 inhibits PAF-induced hypotension in normotensive rats. UR-11353 protects against PAF-induced mortality in mice[1].

体外研究
(In Vitro)

UR-11353 (Compound 4e) 可强效且选择性地抑制血小板活化因子 (PAF) 诱导的富血小板兔血浆聚集，其 IC50 为 0.012 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

UR-11353 相关抗体:
体内研究
(In Vivo)

UR-11353 (Compound 4e) (1 mg/kg；静脉注射；单次给药) 对 PAF 诱导的小鼠死亡表现出强效且持久的保护作用，单次 1 mg/kg 静脉注射给药 24 小时后仍维持 48% 的保护率，静脉注射的 ID50 为 0.023 mg/kg[1]。
UR-11353 (静脉注射；单次给药) 对 PAF 诱发的大鼠低血压具有防护作用，其 ID50 为 0.025 mg/kg[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PAF-induced Swiss mice (male, 22-26 g)[1]
Dosage: 1 mg/kg
Administration: i.v.; single dose
Result: Achieved 100% protection against PAF-induced mortality at 0.5, 2, 3, and 5 hours post-administration.
Achieved 95% protection against PAF-induced mortality at 7 hours post-administration.
Achieved 81% protection against PAF-induced mortality at 17 hours post-administration.
Achieved 48% protection against PAF-induced mortality at 24 hours post-administration.
Exhibited an ID50 of 0.023 mg/kg i.v. for inhibition of PAF-induced mortality.
分子量

611.30

Formula

C34H59ClN2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

UR-11353 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UR-11353138060-13-6UR11353UR 11353Platelet-activating Factor Receptor (PAFR)rabbit platelet-rich plasmaarachidonic acidmiceplatelet aggregationPAFhypotensionplatelet activating factorADPnormotensive ratsInhibitorinhibitorinhibit

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目录号：
HY-182418
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