2. Antibody-drug Conjugate/ADC Related
  3. Antibody-Drug Conjugates (ADCs)
  4. Vandortuzumab vedotin

Vandortuzumab vedotin  (Synonyms: DSTP 3086S; RG 7450; MSTP2109A)

目录号: HY-P99528
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技术支持

Vandortuzumab vedotin (DSTP 3086S; RG 7450) 是一种靶向 STEAP1 的抗体-药物偶联物 (ADC)。Vandortuzumab vedotin 可特异性结合 STEAP1 并触发内化，介导 MMAE 的胞内释放，从而抑制细胞分裂并诱导细胞死亡。Vandortuzumab vedotin 在临床前前列腺癌异种移植模型中表现出抗肿瘤活性。Vandortuzumab vedotin 可用于转移性去势抵抗性前列腺癌的研究。
(粉色: 靶蛋白配体；蓝色: E3 连接酶配体；黑色: 连接子)。

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CAS No. : 1471985-92-8

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规格 价格 是否有货
1 mg ￥5780
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5 mg 询价 询问价格 & 货期

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Vandortuzumab vedotin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vandortuzumab vedotin (DSTP 3086S; RG 7450) is a STEAP1-targeted antibody-drug conjugate (ADC). Vandortuzumab vedotin binds specifically to STEAP1, triggers internalization of the conjugate complex, mediates intracellular release of monomethyl auristatin E, inhibits cell division, and induces cell death. Vandortuzumab vedotin exhibits antitumor activity in preclinical prostate cancer xenografts. Vandortuzumab vedotin can be used for the research of metastatic castration-resistant prostate cancer[1]. (Pink: Target protein ligand; Blue: E3 ligase ligand; Black: linker).

反应种属

Human
IC50 & Target

STEAP1
基因 ID

26872  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
纯度 & 产品资料
参考文献

Vandortuzumab vedotin 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vandortuzumab vedotin1471985-92-8DSTP 3086S RG 7450 MSTP2109ARG7450RG 7450RG-7450Antibody-Drug Conjugates (ADCs)Antibody-Drug Conjugatesprostate cancer xenograftsmonomethyl auristatin Emetastatic castration-resistant prostate cancerantibody-drug conjugatecell divisionSTEAP1cell deathInhibitorinhibitorinhibit

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