2. Metabolic Enzyme/Protease TGF-beta/Smad Epigenetics Apoptosis NF-κB Immunology/Inflammation
  3. Endogenous Metabolite PKC Glycosidase TNF Receptor Reactive Oxygen Species (ROS)
  4. Variegatic acid

Variegatic acid 是一种从担子菌门真菌的次生代谢产物。Variegatic acid 是一种 PKCβ1 抑制剂，其 IC₅₀ 为 36.2 μM。Variegatic acid 抑制抗原或钙离子载体诱导的 β-氨基己糖苷酶 (β-hexosaminidase) 释放 (IC₅₀ 分别为 10.4 μM 和 22.2 μM) 和 TNF-α 分泌 (IC₅₀ 分别为 16.8 μM 和 20.1 μM)。Variegatic acid 可抑制钙激活型 PKCβ1 的酶活性，以 pH 依赖的方式将 Fe (III) 还原为 Fe (II)，进而与 H₂O₂ 反应生成羟基自由基 (·OH)，用于降解木质纤维素。Variegatic acid 可用于研究生物降解和过敏反应。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Variegatic acid

Variegatic acid Chemical Structure

CAS No. : 20988-30-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Variegatic acid 相关抗体

Top Publications Citing Use of Products

查看 PKC 亚型特异性产品:

查看所有亚型
PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Variegatic acid is a secondary metabolite derived from basidiomycete fungi. Variegatic acid is a PKCβ1 inhibitor with an IC₅₀ of 36.2 μM. Variegatic acid inhibits antigen- or calcium ionophore-induced β-hexosaminidase release (IC₅₀ values of 10.4 μM and 22.2 μM, respectively) and TNF-α secretion (IC₅₀ values of 16.8 μM and 20.1 μM, respectively). Variegatic acid suppresses the enzymatic activity of calcium-activated PKCβ1 and reduces Fe(III) to Fe(II) in a pH-dependent manner, enabling the generation of hydroxyl radicals (·OH) through reaction with H₂O₂, which facilitates the degradation of lignocellulose. Variegatic acid is useful for studying biological degradation and allergic responses.

IC50 & Target[2]

PKC-βI

36.2 μM (IC50)

体外研究
(In Vitro)

Variegatic acid (2-90 μM；0-800 min)具有双重生物活性：在酸性环境下能够螯合Fe(III) 并将其还原为 Fe(II)，进而通过类Fenton 反应生成 ROS，如羟基自由基 (·OH) 和超氧阴离子；在无金属离子或高 pH 条件下，则可发挥自由基清除作用，保护真菌免受 ROS 损伤[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Variegatic acid 相关抗体:
分子量

372.29

Formula

C18H12O9
CAS 号
结构分类
初始来源

Tylopilus ballouii
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Variegatic acid 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Variegatic acid20988-30-1Endogenous MetabolitePKCGlycosidaseTNF ReceptorReactive Oxygen Species (ROS)Protein kinase CTumor Necrosis Factor ReceptorTNFRPKCβ1Fe(III)Serpula lacrymansRBL-2H3 cellsβ-hexosaminidaseβ-glucanROSallergyTNF-αlignocellulose cell wallInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Variegatic acid
目录号：
HY-149151
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z