2. Immunology/Inflammation
  3. CD47
  4. VBI-009

VBI-009 是一种靶向 CD47 和 B7-H3 (CD276) 的双特异性抗体。VBI-009 可阻断 CD47-SIRPα 的“别吃我”信号，并将作用范围限定于 CD47+/B7-H3+ 细胞。VBI-009 可在 CD47+/B7-H3+ 肿瘤细胞中诱导抗体依赖性细胞吞噬作用 (ADCP) 和抗体依赖性细胞毒性 (ADCC)。VBI-009 可抑制 CD47+/B7-H3+ 肺癌异种移植模型中的肿瘤生长。VBI-009 可用于肺癌相关研究。

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VBI-009

VBI-009 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
1 mg   询价  
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

Customer Review

VBI-009 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VBI-009 is a CD47 and B7-H3 (CD276) bispecific antibody. VBI-009 blocks CD47-SIRPα 'don't eat me' signals and restricts activity to CD47+/B7-H3+ cells. VBI-009 induces antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent cellular cytotoxicity (ADCC) in CD47+/B7-H3+ tumor cells. VBI-009 inhibits tumor growth in CD47+/B7-H3+ lung cancer xenograft models. VBI-009 can be used for the research of lung cancer[1].

反应种属

Human
体外研究
(In Vitro)

VBI-009 可选择性结合 CD47+/B7-H3+ 肿瘤细胞，对 B7-H3 阴性细胞的结合作用极弱或无结合，且不会与人类红细胞发生显著结合[1]。
VBI-009 可强效阻断 CD47+/B7-H3+ 肿瘤细胞上的 CD47/SIRPα 轴，而对 B7-H3 阴性细胞几乎无活性[1]。
VBI-009 可强效驱动 CD47+/B7-H3+ 肿瘤细胞的抗体依赖性细胞吞噬作用，而对 B7-H3 阴性细胞几乎无活性[1]。
VBI-009 可强效诱导 CD47+/B7-H3+ 肿瘤细胞的抗体依赖性细胞毒性，而对 B7-H3 阴性细胞几乎无活性[1]。
VBI-009 不会诱导人红细胞发生血凝反应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VBI-009 相关抗体:
体内研究
(In Vivo)

VBI-009 可抑制 CD47+/B7-H3+ 肺癌异种移植模型中的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
基因 ID

80381  [NCBI] & 16423  [NCBI]

Accession

Q5ZPR3 & Q61735-1
靶点

B7-H3/CD276 & CD47
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
组分

Please refer to the lot-specific COA for specific buffer information.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VBI-009 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VBI-009VBI009VBI 009CD47Cluster of Differentiation 47MER6OA3lung cancer xenograft modelsB7-H3lung cancerred blood cellantibody-dependent cellular cytotoxicitytumor cellsSIRPαantibody-dependent cellular phagocytosisInhibitorinhibitorinhibit

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产品名称：
VBI-009
目录号：
HY-P992158
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