2. Apoptosis Others
  3. Ferroptosis Drug Derivative
  4. WMK-1

WMK-1 是一种 1,2,4,5-四氧六环衍生物和铁死亡 (ferroptosis) 诱导剂，对癌细胞的细胞毒性比非癌细胞高。WMK-1 可触发癌细胞和癌症干细胞发生铁死亡。WMK-1 可用于癌症的相关研究。

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WMK-1

WMK-1 Chemical Structure

CAS No. : 2814563-83-0

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WMK-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WMK-1 is a 1,2,4,5-tetraoxane derivative and ferroptosis inducer, with significantly higher cytotoxicity against cancer cells than non-cancerous cells. WMK-1 triggers ferroptosis in cancer cells and cancer stem cells. WMK-1 can be used for the research of cancer[1].

体外研究
(In Vitro)

WMK-1 (compound 48) (48 h) 可强效抑制 MDA-MB-231、Hela、T47D、Jurkat、HCT116 和 HL-60 癌细胞的活力，其 IC50 值范围为 1.0 μM 至 6.3 μM[1]。
WMK-1 (48 h) 可强效抑制 HeyA8 卵巢癌细胞 (IC50 = 2.3 μM) 和 HeyA8sp 卵巢癌干细胞球 (IC50 = 1.2 μM) 的活性[1]。
WMK-1 (24 h) 可诱导 HeyA8 卵巢癌细胞、HeyA8 卵巢癌干细胞及 HeyA8 卵巢癌干细胞球发生铁死亡[1]。
WMK-1 (5 μM; 6 h) 可升高 MDA-MB-231 三阴性乳腺癌细胞中的脂质活性氧水平[1]。
WMK-1 (5 μM) 可在指定浓度下于 24 h 内诱导 MDA-MB-231 三阴性乳腺癌细胞发生细胞死亡，且该效应可被 30 μM liproxstatin-1 (HY-12726) 预处理显著逆转[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

WMK-1 相关抗体:
体内研究
(In Vivo)

WMK-1 (compound 48) (腹腔注射，5-10 mg/kg) 可降低裸鼠卵巢癌和三阴性乳腺癌异种移植模型的肿瘤负荷，且未观察到全身或器官相关毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (female)[1]
Dosage: 5 mg/kg; 10 mg/kg
Administration: i.p.
Result: Reduced ovarian cancer xenograft tumor size.
Caused no abnormal behavior or weight loss in treated animals during the entire study period.
分子量

722.69

Formula

C35H51IN2O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

WMK-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WMK-12814563-83-0WMK1WMK 1FerroptosisDrug DerivativeDrug derivativeMDA-MB-231cancer cellsovarian cancerbreast cancerNIH3T3ferroptosiscolon cancercancer stem cellsleukemiaHelaInhibitorinhibitorinhibit

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目录号：
HY-186145
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