86404-63-9 (三唑苯乙酮,Difluoro triazolyl acetophenone)

_99%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ; 50 min, 85 °C

参考文献：

Efficient microwave-assisted synthesis of 1-(1H-indol-1-yl)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents

Lebouvier, Nicolas; et al, Tetrahedron Letters, 2006, 47(36), 6479-6483

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ; 1 - 2 h, rt → 80 °C

参考文献：

Synthesis and biological evaluation of α-triazolyl chalcones as a new type of potential antimicrobial agents and their interaction with calf thymus DNA and human serum albumin

Yin, Ben-Tao; et al, European Journal of Medicinal Chemistry, 2014, 71, 148-159

合成路线：1 步

154534-83-5

_92%

反应条件：

1.1 Solvents: Water ; rt → 0 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; 0 - 5 °C
1.3 Reagents: Sodium nitrite Solvents: Water ; 0 - 5 °C
1.4 Solvents: Dichloromethane
1.5 Reagents: Ammonium hydroxide Solvents: Water ; pH 10

参考文献：

Process for producing 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole and its salts

, Hungary, , ,

合成路线：1 步

102429-07-2

_85%

反应条件：

1.1 Reagents: Triethylamine Solvents: Methanol ; 3 h, 65 °C

参考文献：

Discovery of 1,2,3-selenadiazole analogues as antifungal agents using a scaffold hopping approach

Xu, Hang; et al, Bioorganic Chemistry, 2021, 115,

合成路线：1 步

584-13-4

_79%

反应条件：

1.1 Solvents: Isopropanol

参考文献：

Application of the Stereoselective Cycloaddition of Sulfenic Acids with Alkenes in Target Synthesis

Tisselli, Patrizia, 2004, , ,

合成路线：1 步

584-13-4

反应条件：

1.1 Solvents: Isopropanol ; reflux
1.2 Reagents: Sodium nitrite , Hydrochloric acid Solvents: Water ; 0 °C → rt

参考文献：

Design, synthesis, in vivo and in silico evaluation of phenacyl triazole hydrazones as new anticonvulsant agents

Dehestani, Leila; et al, Bioorganic Chemistry, 2018, 78, 119-129

合成路线：1 步

584-13-4

反应条件：

1.1 Solvents: Isopropanol ; reflux

参考文献：

Synthesis and antifungal studies of bis-mono and difluorophenacyl azolium compounds

Sundaram, Dhanraj T. S. S.; et al, Pharma Chemica, 2014, 6(5), 64-69

合成路线：1 步

41253-21-8

反应条件：

1.1 Solvents: Acetonitrile ; 8 h, reflux

参考文献：

Design, synthesis and antitrypanosomal activity of some nitrofurazone 1,2,4-triazolic bioisosteric analogues

Silva, Fredson T.; et al, European Journal of Medicinal Chemistry, 2016, 121, 553-560

合成路线：1 步

4252-78-2

_71%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Polyethylene glycol Solvents: Acetonitrile ; 4 - 5 h, reflux

参考文献：

Study on the new preparation of fluconazole

Wang, Jian-xiang, Zhongguo Xiandai Yingyong Yaoxue, 2006, 23(1), 35-37

合成路线：1 步

156570-11-5

_55%

反应条件：

1.1 Reagents: Sodium carbonate , Oxygen Catalysts: Tris(2,2′-bipyridyl)ruthenium(II) chloride Solvents: Acetonitrile ; 36 h, rt
1.2 Solvents: Water ; rt

参考文献：

Visible-Light-Induced Regioselective Radical Oxo-Amination of Alkenes with O2 as the Oxygen Source

Wang, Jiayang ; et al, Organic Letters, 2023, 25(28), 5333-5338

合成路线：1 步

_55%

反应条件：

1.1 Reagents: Aluminum chloride Solvents: 1,2-Dichloroethane ; 7 h, 25 °C
1.2 Reagents: Sodium bicarbonate Solvents: Toluene ; 4 h, reflux

参考文献：

Synthesis and biological evaluation of new fluconazole β-lactam conjugates linked via 1,2,3-triazole

Divse, Jaisingh M.; et al, New Journal of Chemistry, 2017, 41(2), 470-479

合成路线：1 步

_55%

反应条件：

1.1 Reagents: Aluminum chloride Solvents: 1,2-Dichloroethane ; 7 h, 25 °C
1.2 Reagents: Sodium bicarbonate Solvents: Toluene ; 4 h, reflux

参考文献：

Synthesis and antifungal activity of 1,2,3-triazole containing fluconazole analogues

Aher, Nilkanth G.; et al, Bioorganic & Medicinal Chemistry Letters, 2009, 19(3), 759-763

合成路线：1 步

_55%

反应条件：

1.1 Reagents: Aluminum chloride Solvents: 1,2-Dichloroethane ; 7 h, 25 °C
1.2 Reagents: Sodium bicarbonate Solvents: Toluene ; 4 h, reflux

参考文献：

Design and synthesis of fluconazole/bile acid conjugate using click reaction

Pore, Vandana S.; et al, Tetrahedron, 2006, 62(48), 11178-11186

合成路线：2 步

372-18-9

107-20-0