934-37-2 (2-甲基咪唑并[1,2-a]吡啶,2-Methylimidazo[1,2-A]pyridine)

_100%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water ; 2 min, rt

参考文献：

Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions

Chapman, Michael R.; Kwan, Maria H. T.; King, Georgina E.; Kyffin, Benjamin A.; Blacker, A. John; et al, Green Chemistry, 2016, 18(17), 4623-4627

合成路线：1 步

2155850-98-7

_98%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Methanol , Water ; 30 min, 15 - 35 °C; 2 h, 20 °C

参考文献：

Process for the manufacture of 6-alkynyl-pyridine derivatives

, World Intellectual Property Organization, , ,

合成路线：1 步

_97%

反应条件：

1.1 Catalysts: Sodium hydroxide Solvents: Water ; 5 min, rt

参考文献：

Synthesis of 2-Carbonylimidazo[1,2-a]pyridines via Iodine-mediated Intramolecular Cyclization of 2-Amino-N-propargylpyridinium Bromides

Pandey, Khima; Kaswan, Pinku; Saroj; Kumar, Anil, ChemistrySelect, 2016, 1(21), 6669-6672

合成路线：1 步

_80%

反应条件：

1.1 Reagents: Sodium methoxide Solvents: Methanol ; 1 d, rt

参考文献：

Synthesis and halogenation of 2-methylimidazo[1,2-a]pyridine. Antimicrobial activity of 3-bromo-2-methyl-1H-imidazo[1,2-a]pyridinium bromide

Kalita, Elena V.; Kim, Dmitry G.; Krynina, Elizaveta M.; Sharutin, Vladimir V.; Shlepotina, Nina M.; et al, Chemistry of Heterocyclic Compounds (New York, 2022, 58(4-5), 227-234

合成路线：1 步

_72%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Cuprous iodide , Dichlorobis(triphenylphosphine)palladium Solvents: Dimethylformamide ; overnight, rt

参考文献：

Preparation of indole and imidazo[1,2-a]pyridine compounds as neuropeptide S antagonists for the treatment of addictive disorders, mood, anxiety and sleep disorders

, World Intellectual Property Organization, , ,

合成路线：1 步

_71%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Cuprous iodide , Dichlorobis(triphenylphosphine)palladium Solvents: Dimethylformamide ; overnight, 25 °C

参考文献：

Structure-Activity Relationship of Imidazopyridinium Analogues as Antagonists of Neuropeptide S Receptor

Patnaik, Samarjit; Marugan, Juan J.; Liu, Ke; Zheng, Wei; Southall, Noel; et al, Journal of Medicinal Chemistry, 2013, 56(22), 9045-9056

合成路线：1 步

_70%

反应条件：

1.1 Solvents: Ethanol , 1,4-Dioxane ; rt; 2 h, rt
1.2 Reagents: Triethylamine ; overnight, reflux

参考文献：

Metal free coupling of heteroaryl N-tosylhydrazones and thiols: Efficient synthesis of sulfides

Garcia-Carrillo, Mario Alfredo; Guzman, Angel; Diaz, Eduardo, Tetrahedron Letters, 2017, 58(20), 1952-1956

合成路线：1 步

67-64-1

_69%

反应条件：

1.1 Catalysts: Tetrabutylammonium tetrafluoroborate , Hydrogen iodide Solvents: Ethanol ; 24 h, 50 °C

参考文献：

Electrochemically initiated intermolecular C-N formation/cyclization of ketones with 2-aminopyridines: an efficient method for the synthesis of imidazo[1,2-a]pyridines

Feng, Mei-Lin; Li, Shu-Qi; He, Hui-Zi; Xi, Long-Yi; Chen, Shan-Yong; et al, Green Chemistry, 2019, 21(7), 1619-1624

合成路线：1 步

_66%

反应条件：

1.1 Reagents: Triethylamine , Iodobenzene Catalysts: Cuprous iodide , Dichlorobis(triphenylphosphine)palladium Solvents: Dimethylformamide ; rt
1.2 12 h, rt

参考文献：

Pd-Cu catalyzed heterocyclization during Sonogashira coupling: synthesis of 2-benzylimidazo[1,2-a]pyridine

Bakherad, Mohammad; Nasr-Isfahani, Hossein; Keivanloo, Ali; Doostmohammadi, Nesa, Tetrahedron Letters, 2008, 49(23), 3819-3822

合成路线：1 步

78-95-5

_57%

反应条件：

1.1 Solvents: Ethanol ; rt; 16 h, reflux

参考文献：

Imidazopyridinyl thiazolyl compounds as histone deacetylase inhibitors and their preparation and use in the treatment of diseases

, World Intellectual Property Organization, , ,

合成路线：1 步

67-64-1

_56%

反应条件：

1.1 Reagents: Oxygen Catalysts: Sodium iodide , Cerium trichloride Solvents: Ethanol ; 20 h, 80 °C

参考文献：

Aerobic Multicomponent Tandem Synthesis of 3-Sulfenylimidazo[1,2-a]pyridines from Ketones, 2-Aminopyridines, and Disulfides

Ge, Wenlei; Zhu, Xun; Wei, Yunyang, European Journal of Organic Chemistry, 2013, 2013(27), 6015-6020

合成路线：1 步

_55%

参考文献：

Metal-Free Mediated C-3 Methylsulfanylation of Imidazo[1,2-a]-pyridines with Dimethyl Sulfoxide as a Methylsulfanylating Agent

Chen, Zhengkai ; Cao, Gangjian; Zhang, Fengjin; Li, Hongli; Xu, Jianfeng ; et al, Synlett, 2017, 28(14), 1795-1800

合成路线：1 步

78-95-5

_52%

反应条件：

1.1 Solvents: Tetrahydrofuran ; overnight, rt
1.2 Solvents: Ethanol ; 3 h, rt → reflux

参考文献：

The imidazopyridine derivative JK184 reveals dual roles for microtubules in hedgehog signaling

Cupido, Tommaso; Rack, Paul G.; Firestone, Ari J.; Hyman, Joel M.; Han, Kyuho; et al, Angewandte Chemie, 2009, 48(13), 2321-2324

合成路线：1 步

67-64-1

_51%

反应条件：

1.1 Reagents: Oxygen Catalysts: Boron trifluoride etherate , Cuprous iodide Solvents: Dimethylformamide ; 24 h, 60 °C

参考文献：

Copper(I) Iodide-Catalyzed Aerobic Oxidative Synthesis of Imidazo[1,2-a]pyridines from 2-Aminopyridines and Methyl Ketones

Chandra Mohan, Darapaneni; Reddy Donthiri, Ramachandra; Nageswara Rao, Sadu; Adimurthy, Subbarayappa, Advanced Synthesis & Catalysis, 2013, 355(11-12), 2217-2221

合成路线：1 步

_50%

反应条件：

1.1 Solvents: Ethanol , Water ; rt; 2 h, rt
1.2 Reagents: Triethylamine ; rt; overnight, reflux

参考文献：

Synthesis and cytotoxic activity of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidine derivatives

Vilchis-Reyes, Miguel Angel; Zentella, Alejandro; Martinez-Urbina, Miguel Angel; Guzman, Angel; Vargas, Omar; et al, European Journal of Medicinal Chemistry, 2010, 45(1), 379-386

合成路线：1 步

78-95-5

_48%

反应条件：

1.1 Solvents: 1,2-Dimethoxyethane ; rt; rt → reflux; 48 h, reflux

参考文献：

Preparation of fused heterocyclic imidazolyl compounds for treatment of HDAC- and CDK-mediated diseases

, World Intellectual Property Organization, , ,

合成路线：1 步

_23%

反应条件：

1.1 Solvents: Ethanol , 1,4-Dioxane ; 2 h, rt
1.2 Reagents: Triethylamine ; overnight, 90 °C

参考文献：

Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083)

Zhou, Han-Jie; Wang, Jinhai; Yao, Bing; Wong, Steve; Djakovic, Stevan; et al, Journal of Medicinal Chemistry, 2015, 58(24), 9480-9497

合成路线：1 步

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Ethanol ; 8 - 10 h, rt
1.2 Reagents: Water ; rt

参考文献：

Electrochemically Promoted [3+2] Annulation of Imidazo[1,2-a]pyridine with Alkynes

Ping, Meng-Qi; Guo, Ming-Zhong; Li, Rui-Tao; Wang, Zi-Chen; Ma, Cheng; et al, Organic Letters, 2022, 24(40), 7410-7415

合成路线：1 步

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Ethanol ; reflux

参考文献：

Unconventional Reactivity with DABCO-Bis(sulfur dioxide): C-H Bond Sulfenylation of Imidazopyridines

Le Bescont, Julie; Breton-Patient, Chloe; Piguel, Sandrine, European Journal of Organic Chemistry, 2020, 2020(14), 2101-2109

合成路线：1 步

816-40-0