954-16-5 (2,4,6-三甲基苯甲酮,2,4,6-Trimethylbenzophenone)

_100%

反应条件：

1.1 Catalysts: Iron oxide (Fe2O3) ; 3 h, 110 °C

参考文献：

An efficient Fe2O3/HY catalyst for Friedel-Crafts acylation of m-xylene with benzoyl chloride

Mu, Manman; Chen, Ligong; Liu, Yunlong; Fang, Wangwang; Li, Yang, RSC Advances, 2014, 4(70), 36951-36958

合成路线：1 步

_100%

反应条件：

1.1 Catalysts: Hydrochloric acid , Uranyl chloride Solvents: Water

参考文献：

Acylation of aromatic compounds

, France, , ,

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Iodine , Phosphorus trichloride ; 36 h, 160 °C

参考文献：

Iodine Promoted Conversion of Esters to Nitriles and Ketones under Metal-Free Conditions

Xiao, Jing ; Guo, Fengzhe; Li, Yinfeng; Li, Fangshao; Li, Qiang ; et al, Journal of Organic Chemistry, 2021, 86(2), 2028-2035

合成路线：1 步

65-85-0

_99%

反应条件：

1.1 Reagents: Trifluoroacetic anhydride Catalysts: Bismuth triflate ; 0 °C; 12 h, 30 °C

参考文献：

The Friedel-Crafts acylation of aromatic compounds with carboxylic acids by the combined use of perfluoroalkanoic anhydride and bismuth or scandium triflate

Matsushita, Yoh-Ichi; Sugamoto, Kazuhiro; Matsui, Takanao, Tetrahedron Letters, 2004, 45(24), 4723-4727

合成路线：1 步

1804967-87-0

5980-97-2

_98%

反应条件：

1.1 Reagents: Sodium carbonate Catalysts: Palladium diacetate , Phosphine, tricyclohexyl-, tetrafluoroborate(1-) (1:1) Solvents: 1,4-Dioxane ; rt; 15 h, 120 °C

参考文献：

Sterically Hindered Ketones via Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling of Amides by N-C(O) Activation

Liu, Chengwei ; Lalancette, Roger ; Szostak, Roman; Szostak, Michal, Organic Letters, 2019, 21(19), 7976-7981

合成路线：1 步

_98%

反应条件：

1.1 Catalysts: Copper iron oxide (CuFe2O4) ; 18 h, 35 - 38 °C

参考文献：

Catalytic Friedel-Crafts acylation: magnetic nanopowder CuFe2O4 as an efficient and magnetically separable catalyst

Parella, Ramarao; Naveen; Kumar, Amit; Babu, Srinivasarao Arulananda, Tetrahedron Letters, 2013, 54(13), 1738-1742

合成路线：1 步

_96%

反应条件：

1.1 Catalysts: Potassium chloride (PIZP-catalyst) , Phosphoric acid (PIZP-catalyst) , Zirconium oxychloride (PIZP-catalyst) , Iron chloride (FeCl3) (PIZP-catalyst) ; 2.5 h, 110 °C

参考文献：

A novel sol-gel synthesized catalyst for Friedel-Crafts benzoylation reaction under solvent-free conditions

Gawande, M. B.; Deshpande, S. S.; Sonavane, S. U.; Jayaram, R. V., Journal of Molecular Catalysis A: Chemical, 2005, 241(1-2), 151-155

合成路线：1 步

_96%

反应条件：

1.1 Catalysts: Tetrakis[1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-N-[(1,1,2,2,3,3,4,4,5… Solvents: Chlorobenzene ; 3 h, 110 °C; 1 h, 100 °C

参考文献：

Hf[N(SO2C8F17)2]4-catalyzed Friedel-Crafts acylation in a fluorous biphase system

Hao, Xiuhua; Yoshida, Akihiro; Nishikido, Joji, Tetrahedron Letters, 2005, 46(15), 2697-2700

合成路线：1 步

65-85-0

_96%

反应条件：

1.1 Reagents: Trifluoroacetic acid , 2-Pyridyl triflate Solvents: Trifluoroacetic acid

参考文献：

2-(Trifluoromethylsulfonyloxy)pyridine as a reagent for ketone synthesis from carboxylic acids and aromatic hydrocarbons

Keumi, Takashi; Yoshimura, Kiichiro; Shimada, Masakazu; Kitajima, Hidehiko, Bulletin of the Chemical Society of Japan, 1988, 61(2), 455-9

合成路线：1 步

36967-85-8

_96%

参考文献：

Electrophilic aromatic substitution. 25. Carboxylic trifluoromethanesulfonic anhydrides as highly effective acylation agents. Perfluoroalkanesulfonic acid catalyzed acylation of arenes

Effenberger, Franz; Sohn, Erich; Epple, Gerhard, Chemische Berichte, 1983, 116(3), 1195-208

合成路线：1 步

65-85-0

_95%

反应条件：

1.1 Reagents: Benzotrichloride Catalysts: Iron oxide (Fe2O3), hydrate (1:2) ; 8 h, 0.18 MPa, 125 °C

参考文献：

Preparation of benzophenone derivatives

, China, , ,

合成路线：1 步

938-18-1

934-56-5

_95%

反应条件：

1.1 Catalysts: 2623973-37-3 Solvents: Benzene-d6 ; rt → 75 °C; 12 h, 75 °C

参考文献：

Phosphine-Borane Ligands Induce Chemoselective Activation and Catalytic Coupling of Acyl Chlorides at Palladium

Boudjelel, Maxime; Sadek, Omar ; Mallet-Ladeira, Sonia; Garcia-Rodeja, Yago; Sosa Carrizo, E. Daiann ; et al, ACS Catalysis, 2021, 11(7), 3822-3829

合成路线：1 步

_95%

反应条件：

1.1 Catalysts: Bismuth triflate Solvents: 1-Butyl-3-methylimidazolium trifluoromethanesulfonate ; 30 min, 140 °C

参考文献：

Improvement of the Friedel-Crafts benzoylation by using bismuth trifluoromethanesulfonate in 1-butyl-3-methylimidazolium trifluoromethanesulfonate ionic liquid under microwave irradiation

HoangTran, Phuong; BichLe Do, Ngoc; NgocLe, Thach, Tetrahedron Letters, 2014, 55(1), 205-208

合成路线：1 步

155632-06-7

2633-66-1

_95%