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| 中文名称： | 豆蔻明 | 中文别名： | 豆蔻明 |
|---|---|---|---|
| 英文名称： | Cardamomin | CAS： | 18956-16-6 |
| 产品分类： | 小分子化合物 | 纯度： | ≥98% / HPLC≥98% |
| 产品编号 | 品牌 | 纯度 | 规格 | 库存 | 价格 |
|---|---|---|---|---|---|
| IC1030 | 索莱宝 | ≥98% | 10mM*1mlinDMSO | 现询 | 面议 |
| IC1030 | 索莱宝 | HPLC≥98% | 5mg | 有现货 | 670.00 元 |
| IC1030 | 索莱宝 | HPLC≥98% | 10mg | 有现货 | 1,150.00 元 |
| IC1030 | 索莱宝 | HPLC≥98% | 50mg | 有现货 | 3,490.00 元 |
| 标准名称: | 豆蔻明 | 英文名称： | Cardamonin |
|---|---|---|---|
| CAS： | 18956-16-6 | 分子式： | C16H14O4 |
| 分子量： | 270.279964923859 | 颜色与性状： | No data available |
| 密度： | 1.282g/cm3 | 沸点： | 484.5oC at 760 mmHg |
| 熔点： | No data available | 水溶性： |
| CAS | 18956-16-6 |
| 中文名称 | 豆蔻明 |
| 英文名称 | Cardamomin |
| 别名 | Alpinetinchalcone |
| 分子式 | C16H14O4 |
| 分子量 | 270.28 |
| 规格 | 10mg ; 5mg ; 50mg |
| 溶解性 | Soluble in DMSO |
| 纯度 | HPLC≥98% |
| 级别 | Cell Culture |
| 外观(性状) | Light yellow to yellow Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| 运输条件 | 冷藏运输 |
| MDL | MFCD00238554 |
| SMILES | COC1=CC(O)=CC(O)=C1C(=O)C=CC1=CC=CC=C1 |
| InChIKey | NYSZJNUIVUBQMM-BQYQJAHWSA-N |
| InChI | InChI=1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+ |
| PubChem CID | 641785 |
| 靶点 | Calcium Channel |
| 通路 | Membrane Transporter&Ion Channel;Neuronal Signaling |
| 背景说明 | Cardamomin是一种新型的hTRPA1离子通道拮抗剂。 |
| 生物活性 | Cardamonin (Alpinetin chalcone)天然存在于良姜属物种的果实中，具有抗炎和抗肿瘤活性。它是一种新型的hTRPA1离子通道拮抗剂，IC50为454 nM，而不与TRPV1和TRPV4相互作用。[1-3] |
| In Vitro | Cardamonin selectively blocks TRPA1 activation while does not interact with TRPV1 nor TRPV4 channel. A concentration-dependent inhibitory effect is observed with IC50 of 454 nM. Cardamonin does not significantly reduce HEK293 cell viability，nor does it impair cardiomyocyte constriction[1]. In vitro，cardamonin(25 and 50 μM)concentration dependently inhibits endothelium permeability and down-regulates phosphorylation of P38 in rat lung microvascular endothelial cells induced by lipopolysaccharide(LPS). In RAW 264.7 macrophage cells，cardamonin also shows selective inhibition of P38 phosphorylation induced by LPS[2]. Cardamonin inhibits the growth of several cancer cell types including breast cancer，glioblastoma，ovarian，prostate，and lung. Treatment of cardamonin in CRC cell lines induces cell cycle arrest mostly in the S phase of cell cycle. It activates both apoptosis and induces cell cycle arrest to inhibit the cell proliferation. Cardamonin is known to inhibit various signaling pathways which play a major role in the process of inflammation and cancer. This natural product inhibits the phosphorylation and translocation of both STAT3 and NF-κB. Cardamonin also inhibits angiogenesis through downregulation of miR-21 expression[3]. |
| In Vivo | Cardamonin(30 and 100 mg/kg)significantly elevates the survival rate of septic mice，alleviates ALI and lung microvascular leak，and lowers the serum levels of proinflammatory cytokines TNF-α，IL-1β，and IL-6[2]. Cardamonin inhibits Azoxymethane-induced colorectal cancer(CRC). Its treatment inhibits the tumor incidence，tumor multiplicity，Ki-67 and β-catenin positive cells. The preclinical pharmacokinetics and ADME characterization of cardamonin in mice reports that cardamonin is highly permeable with an effective permeability value in ileum is(Peff)3 × 10 4 which is highly significant. Within 30 minutes of oral dosing，cardamonin is distributed to various tissues[3]. |
| 细胞实验 | Endothelial cells are preincubated with different concentrations of cardamonin for 12 h. Then，Trypan blue-labeled BSA is added into the upper compartments of Transwell membranes. Thirty minutes later，cells are stimulated by LPS(1 μg/mL)for 1 h. Trypan blue dye content in the lower compartment is assayed by spectrophotometry at 590 nm and expressed as a percentage of the maximum concentration that would have been achieved at equilibrium.[2] |
| 动物实验 | Animal Models: Male ICR mice; Dosages: 0，30，and 100 mg/kg; Administration: oral[2] |
| 数据来源文献 | [1] Wang S， et al. Molecules. 2016， 21(9). pii: E1145. [2] Wei Z， et al. J Biochem Mol Toxicol. 2012， 26(7):282-90. [3] Shirley James， et al. Scientific Reports. 2017， 7: 13945. |
| 单位 | 瓶 |
| 1mM-5mg | 18.4993mL |
| 1mM-1mg | 3.6999mL |
| 1mM-10mg | 36.9987mL |
| 5mM-1mg | 0.74mL |
| 5mM-5mg | 3.6999mL |
| 5mM-10mg | 7.3997mL |
| 10mM-1mg | 0.37mL |
| 10mM-5mg | 1.8499mL |
| 10mM-10mg | 3.6999mL |
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