4-((3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorophenyl)(hydroxy)methyl)phthalazin-1(2H)-one

Catalogue Number C992278 Chemical Name 4-((3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorophenyl)(hydroxy)methyl)phthalazin-1(2H)-one Synonyms Olaparib Metabolite M15 Number 1460272-53-0 Molecular Formula C₂₄H₂₃FN₄O₄ Appearance White to Off-White Solid Melting Point 234 - 238°C Molecular Weight 450.46 Storage -20°C, Inert atmosphere Solubility DMSO (Slightly), Methanol (Slightly, Sonicated) Category Research Tools; Molecular Biology; Enzyme Activators and Inhibitors; Applications 4-((3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorophenyl)(hydroxy)methyl)phthalazin-1(2H)-one is an impurity of Olaparib (O514500), a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Olaparib has been shown to induce significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Recent studies show that Olaparib increases radiosensitivity of a lung tumor xenograft, making it a potential candidate for use in combination with radiotherapy. Potent PARP inhibitor. References Weston, V.J. et al.: Blood, 116, 4578 (2010); Senra, J.M. et al.: Mol. Cancer Therap., 10, 1949 (2011); Schaefer, N.G. et al.: Nuc. Med. Comm., 32, 1046 (2011);