4-苯甲基-2-甲基-1,2,4-噻二唑烷-3,5-二酮

英文别名 TDZD-8|327036-89-5|4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione|GSK-3beta Inhibitor I|TDZD 8|NP 01139|2-methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione|4-Benzyl-2-methyl-[1,2,4]thiadiazolidine-3,5-dione|GSK-3beta Inhibitor I;NP 01139|thiadiaz
规格或纯度 ≥98%
英文名称 TDZD-8 生化机理 TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.Selective, non-ATP competitive GSK-3β inhibitor (IC 50 = 2 µM). Binds to the active site of GSK3β. Also inhibits PKC activity (IC 50 values are 1.4, 1.1 and 5.5 µM at βI, δ and ι isoforms respectively).
储存温度 -20°C储存
运输条件 超低温冰袋运输 备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍 TDZD-8(NP 01139)是thiadiazolidinone的衍生物，是非ATP竞争性GSK-3β抑制剂，IC50为2 μM，对Cdk-1/cyclin B，CK-II，PKA和PKC无活性。TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program;TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb. TDZD-8(NP 01139) is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM); does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program;TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.