产品货号：C051600
产品名称：Cabozantinib N-oxide
Synonyms:N-[4-[(6,7-Dimethoxy-1-oxido-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
CAS号：1621681-63-7
分子式：C₂₈H₂₄FN₃O₆
Appearance:White to Off-White Solid
Melting Point:143 - 147°C
分子量：517.51
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用：Cabozantinib N-oxide is a impurity of Cabozantinib (X745500), a medication used to treat medullary thyroid cancer. As well, it can be used in biological study. Computational network biological approach based on pathway cross-talk inhibition identified new synergistic drug combinations using raloxifene and cabozantinib for treatment of human breast cancer in xenograft mouse model. Potent c-MET inhibitor.
参考文献：Jaeger, S., et al.: Cancer Res, 77, 459-469 (2017)
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