2. Anti-infection Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Bacterial Reactive Oxygen Species (ROS)
  4. Antibacterial agent 337

Antibacterial agent 337 是一种抗菌剂。Antibacterial agent 337 可特异性与细菌细胞膜中的 PG 相互作用，引发膜破坏事件、膜去极化、通透性增加、细胞质泄漏、ROS 积累及快速细菌 (bacterial) 死亡。Antibacterial agent 337 可抑制生物膜形成、破坏成熟生物膜。Antibacterial agent 337 在小鼠金黄色葡萄球菌皮肤脓肿模型中展现出强效的体内抗菌效力。Antibacterial agent 337 可用于革兰氏阳性菌感染的研究，包括耐甲氧西林金黄色葡萄球菌感染、耐万古霉素粪肠球菌感染及细菌生物膜感染。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Antibacterial agent 337

Antibacterial agent 337 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Antibacterial agent 337 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antibacterial agent 337 is an antibacterial agent. Antibacterial agent 337 specifically interacts with PG in bacterial cell membranes, triggering membrane disruption, membrane depolarization, increased permeability, cytoplasmic leakage, ROS accumulation and rapid bacterial death. Antibacterial agent 337 inhibits biofilm formation and disrupts mature biofilms. Antibacterial agent 337 exhibits potent in vivo antibacterial efficacy in a mouse model of Staphylococcus aureus skin abscess. Antibacterial agent 337 can be used in studies of Gram-positive bacterial infections, including methicillin-resistant Staphylococcus aureus infections, vancomycin-resistant Enterococcus faecalis infections and bacterial biofilm infections[1].

体外研究
(In Vitro)

Antibacterial agent 337 (Compound 10 b) (0-64 μg/mL; 8 h for S. aureus, 2 h for HEK293T) 可呈浓度依赖性地选择性中和 S. aureus ATCC25923 的阴离子表面电荷，而对 HEK293T 哺乳动物细胞的 zeta 电位无影响[1]。
Antibacterial agent 337 (0-128 μg/mL，24 h) 对革兰氏阳性菌 (S. aureus 25923、S. aureus 43300、E. faecalis 29212、E. faecalis 51299、B. subtilis 9372) 强效抑菌，MIC = 1-4 μg/mL，对革兰氏阴性菌活性弱[1]。
Antibacterial agent 337 抑制 S. aureus ATCC25923 生物膜形成，特异性结合磷脂酰甘油 (PG)，显著升高 ROS[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 337 相关抗体:
体内研究
(In Vivo)

Antibacterial agent 337 (5-10 mg/kg；皮下注射；单次) 在小鼠金黄色葡萄球菌皮肤脓肿模型中展现出强效的体内抗菌效力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (male, 6-8 weeks old)[1]
Dosage: 5 mg/kg; 10 mg/kg
Administration: s.c.; single dose
Result: Reduced the bacterial load by 1.28 log10 CFU/g (93.38% decrease in bacterial survival) at 5 mg/kg.
Reduced the bacterial load by 2.99 log10 CFU/g (99.89% decrease in bacterial survival) at 10 mg/kg.
Significantly reduced pustule formation and inflammatory infiltration at 5 mg/kg.
Eliminated obvious inflammatory cells in epidermal and dermal layers, with tissue architecture resembling uninfected controls at 10 mg/kg.
分子量

1343.33

Formula

C78H92Br2N2O4P2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antibacterial agent 337 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 337Antibacterial agent337Antibacterial agent-337BacterialReactive Oxygen Species (ROS)methicillin-resistant staphylococcus aureus infectiongram-positive bacterial infectionsS. aureus ATCC25923bacterial membranesreactive oxygen speciesHEK293T mammalian cellsbacterial biofilm infectionsanionic phosphatidylglycerolmurine S. aureus skin abscess modelvancomycin-resistant enterococcus faecalis infectionInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Antibacterial agent 337
目录号：
HY-182798
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z