2. Anti-infection
  3. Fungal
  4. Antifungal agent-161

Antifungal agent-161 (Compound 7) 是一种抗真菌 (Antifungal) 剂。Antifungal agent-161 可强效抑制白色念珠菌 ATCC 36082 (MIC 为 1.32 μM) 和光滑念珠菌 ATCC 2001 (MIC 为 1.66 μM)。Antifungal agent-161 可降低感染小鼠的真菌载量，并清除白色念珠菌和光滑念珠菌感染。Antifungal agent-161 可用于念珠菌病的研究。

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Antifungal agent-161

Antifungal agent-161 Chemical Structure

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Antifungal agent-161 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antifungal agent-161 (Compound 7) is an Antifungal agent. Antifungal agent-161 potently inhibits Candida albicans ATCC 36082 (with a MIC of 1.32 μM) and Candida glabrata ATCC 2001 (with a MIC of 1.66 μM). Antifungal agent-161 reduces fungal loads in infected mice and eliminates Candida albicans and Candida glabrata infections. Antifungal agent-161 can be used for the research of candidiasis[1].

体外研究
(In Vitro)

Antifungal agent-161 (0.39-100 μg/mL; 24 h) 在体外可强效抑制白色念珠菌 ATCC 36082 (MIC 为 1.32 μM) 和光滑念珠菌 ATCC 2001 (MIC 为 1.66 μM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antifungal agent-161 相关抗体:
体内研究
(In Vivo)

Antifungal agent-161 (2 mg/kg；每日 1 次；连续 6 天) 在小鼠系统性念珠菌病模型中可使存活率达到 88%，并将白色念珠菌的肾脏真菌负荷降至 228-318 CFU/g[1]。
Antifungal agent-161 (2 mg/kg；每日 1 次；连续 6 天) 在小鼠系统性念珠菌病模型中可使存活率达到 80%，并将 C. glabrata 的肾脏真菌载量降至 337-470 CFU/g[1]。
Antifungal agent-161 (腹腔注射，2-20 mg/kg) 在健康 BALB/c 小鼠中，腹腔注射剂量高达 20 mg/kg 时未表现出急性毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (female, 6-8 weeks old, 25-30 g, immunocompromised with cyclophosphamide, inoculated with Candida albicans)[1]
Dosage: 2 mg/kg
Administration: daily; 6 days
Result: Achieved an 88% survival rate (vs. 50% in infection control group).
Reduced kidney fungal burden to 228-318 CFU/g (vs. 2100-2300 CFU/g in infection control group).
Preserved intact red and white pulp in spleen tissue with no Candida albicans hyphae.
Maintained intact glomeruli, Bowman's capsules, and convoluted tubules in kidney tissue with only mild collagen dispersion and no visible fungal infestation.
Animal Model: BALB/c (female, 6-8 weeks old, 25-30 g, immunocompromised with cyclophosphamide, inoculated with Candida glabrata)[1]
Dosage: 2 mg/kg
Administration: daily; 6 days
Result: Achieved an 80% survival rate (vs. 40% in infection control group).
Reduced kidney fungal burden to 337-470 CFU/g (vs. 1670-1850 CFU/g in infection control group).
Preserved intact red and white pulp in spleen tissue with moderate immune cell inflammation and no Candida glabrata infestation.
Maintained intact proximal and distal convoluted tubules, glomeruli, and Bowman's capsules in kidney tissue with normal histology.
分子量

469.83

Formula

C26H23Cl3N2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antifungal agent-161 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antifungal agent-161Antifungal agent161Antifungal agent 161Fungalhuman fibroblast BJ cellsCandida glabratamembrane permeabilizationCandida albicansBALB/c micecandidiasismembrane depolarizationhuman skin normal cellsmembrane disruptormurine systemic candidiasis modelInhibitorinhibitorinhibit

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