2. Others Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Drug Derivative Reactive Oxygen Species (ROS)
  4. BO-653

BO-653 是一种具有口服活性的抗动脉粥样硬化抗氧化剂，对 LDL 具有高结合亲和力。BO-653 可清除亚油酸过氧自由基，抑制亚油酸自氧化过程中的脂质过氧化，并强效抑制 LDL 氧化。BO-653 可增强分离得到的兔 LDL 的抗氧化能力。BO-653 在包括渡边遗传性高脂血症兔在内的多种动物模型中发挥显著的抗动脉粥样硬化作用。BO-653 可用于动脉粥样硬化的相关研究。

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BO-653

BO-653 Chemical Structure

CAS No. : 157360-23-1

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BO-653 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BO-653 is an oral active antiatherogenic antioxidant with high binding affinity to LDL. BO-653 scavenges linoleate peroxyl radicals and suppresses lipid peroxidation during linoleic acid autoxidation, and potently inhibits LDL oxidation. BO-653 enhances the oxidation resistance of isolated rabbit LDL. BO-653 exerts significant antiatherogenic effects in multiple animal models including Watanabe heritable hyperlipidemic rabbits. BO-653 can be used for the research of atherosclerosis[1].

体外研究
(In Vitro)

BO-653 (1f) (孵育 10 分钟) 在无细胞实验中可强效抑制亚油酸自氧化，其 IC50 为 4.6 μM[1]。
BO-653 (24 h) 可抑制 SLO 和 CuSO4 诱导的兔 LDL 氧化[1]。
BO-653 (1, 10 μM; 24 h) 可强效抑制经 CuSO4 氧化的兔低密度脂蛋白 (LDL) 的电泳迁移率变化；经 1 μM 该试剂处理后，LDL 的迁移率与天然 LDL 相近[1]。
BO-653 (1, 10 μM; 24 h) 可强效抑制经 SLO 氧化的兔低密度脂蛋白 (LDL) 的电泳迁移率变化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BO-653 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route Plasma Concentration
Rabbit[1] 250 mg/kg p.o. 2.22 μg/mL
体内研究
(In Vivo)

BO-653 (1f) (250 mg/kg；口服；每日 1 次；连续 9 天) 可使 WHHL 兔体内 LDL 浓度升高，并对 LDL 氧化具有强效抵抗作用，证实其作为抗动脉粥样硬化抗氧化剂的有效性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

388.63

Formula

C26H44O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BO-653 相关分类

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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BO-653157360-23-1BO653BO 653Drug DerivativeReactive Oxygen Species (ROS)Drug derivativesoybean lipoxygenaselinoleate peroxyl radicalsWatanabe heritable hyperlipidemic rabbitscupric ionsLDLatherosclerosislinoleic acid autoxidationlipid peroxidationInhibitorinhibitorinhibit

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