2. Immunology/Inflammation
  3. Glycoprotein VI
  4. CBP-DWS

CBP-DWS 是一种特异性结合结肠癌细胞和组织的 12 氨基酸线性多肽。CBP-DWS 可阻断抗 Glypican-3 抗体与过表达 Glypican-3 的结肠癌细胞结合。CBP-DWS 可用于结肠癌成像探针、恶性肿瘤靶向示踪剂等研究。

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CBP-DWS

CBP-DWS Chemical Structure

CAS No. : 1840906-92-4

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CBP-DWS 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CBP-DWS is a 12-amino-acid linear polypeptide that specifically binds to colon cancer cells and tissues. CBP-DWS blocks the binding of anti-Glypican-3 antibodies to colon cancer cells with overexpressed Glypican-3. CBP-DWS can be used in research such as colon cancer imaging probes and targeted tracers for malignant tumors[1].

体外研究
(In Vitro)

CBP-DWS (5-160 μM; 15 min-1 h) 以浓度依赖的方式特异性且强效地结合人结肠癌细胞系 (COLO320HSR、HCT116、HT29、SW480、LoVo)，而对正常人肠上皮细胞系 NCM460 的结合作用可忽略不计[1]。
CBP-DWS (20 μM; 15 min) 可在体外特异性结合人结肠癌组织切片，而对邻近正常结肠组织切片的结合作用可忽略不计[1]。
CBP-DWS 可与抗 Glypican-3 抗体竞争结合人结肠癌细胞系 HCT116 和 LoVo，表明 Glypican-3 是其潜在的靶受体[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CBP-DWS 相关抗体:
分子量

1539.60

Formula

C70H94N18O22
CAS 号
Sequence

Asp-Trp-Ser-Ser-Trp-Val-Tyr-Arg-Asp-Pro-Gln-Thr
Sequence Shortening

DWSSWVYRDPQT
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CBP-DWS 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CBP-DWS1840906-92-4Glycoprotein VIGPVISW480LoVoCOLO320HSRnormal intestinal epithelial cellscolon cancercolon cancer cellsHCT116colon cancer tissuesHT29Glypican-3Inhibitorinhibitorinhibit

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