2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK2-IN-57

CDK2-IN-57 是一种选择性的 Cdk2/CycE 复合物抑制剂，其 IC50 为 2.8 nM。CDK2-IN-57 可抑制 Cdk1/2 激酶活性，阻断细胞周期进程，诱导 G0 期细胞周期阻滞，并阻止细胞进入 S 期。CDK2-IN-57 可用于结肠癌的相关研究。

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CDK2-IN-57

CDK2-IN-57 Chemical Structure

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CDK2-IN-57 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK2-IN-57 is a selective Cdk2/CycE inhibitor with an IC50 of 2.8 nM. CDK2-IN-57 inhibits Cdk1/2 kinase activity, blocks cell cycle progression, induces G0-phase cell cycle arrest, and prevents S-phase entry. CDK2-IN-57 can be used for the research of colon carcinoma[1].

IC50 & Target[1]

CDK2/Cyc E

2.8 nM (IC50)

体外研究
(In Vitro)

CDK2-IN-57 (Compound 22) 可强效抑制纯化的 Cdk2/CycE 复合物，其 IC50 为 2.8 nM[1]。
CDK2-IN-57 (20 nM-100 μM；48 小时) 可在 HCT-116 结肠癌细胞中诱导剂量依赖性 G0 期细胞周期阻滞并降低细胞活力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDK2-IN-57 相关抗体:

Cell Cycle Analysis[1]

Cell Line: HCT-116 colon cancer cells
Concentration: 20 nM; 50 nM; 100 nM; 200 nM; 390 nM; 780 nM; 1.56 μM; 3.13 μM; 6.25 μM; 12.5 μM; 25 μM; 50 μM; 100 μM
Incubation Time: 48 h
Result: Reduced cell number of cells positive for Edu and pHH3 in a dose-dependent manner.
Induces dose-responsive cell cycle arrest at G0 and reduced viability.
分子量

414.50

Formula

C22H30N4O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK2-IN-57 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK2-IN-57CDKCyclin dependent kinasephospho-Histone H3Cdk1/2 kinaseCdk2/CycE complexS-phasecancer cell viabilityG0-phase cell cycle arrestcell cycle progressioncolon carcinomaHCT-116 colon cancer cellsInhibitorinhibitorinhibit

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产品名称：
CDK2-IN-57
目录号：
HY-183146
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