2. Anti-infection
  3. Fungal
  4. CHNQD-02204

CHNQD-02204 是一种强效的和选择性的抗真菌剂，对白色念珠菌具有体外活性，其 MIC 为 0.025 μg/mL。CHNQD-02204 可抑制麦角固醇生成，破坏白色念珠菌细胞膜完整性和生物膜的形成，抑制白色念珠菌从酵母态到菌丝态的形态转换。CHNQD-02204 可用于念珠菌感染的相关研究。

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CHNQD-02204

CHNQD-02204 Chemical Structure

CAS No. : 3094676-22-6

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CHNQD-02204 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CHNQD-02204 is a potent and selective antifungal agent with in vitro activity against Candida albicans, with a MIC of 0.025 μg/mL. CHNQD-02204 inhibits ergosterol biosynthesis, disrupts the membrane integrity and biofilm formation of Candida albicans, and suppresses the morphological transition of Candida albicans from yeast to hyphal form. CHNQD-02204 can be used in studies related to candidal infections[1].

体外研究
(In Vitro)

CHNQD-02204 (0.05 μg/mL; 2 h) 会破坏白色念珠菌 ATCC 10231 的细胞表面完整性，导致细胞皱缩和凹陷[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CHNQD-02204 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route T1/2 Tmax Cmax AUC0-t AUC0-∞ CL
Rat[1] 2.5 mg/kg i.v. 12.7 min 1 min 5952.5 ng/mL 31896.7 min·ng/mL 46463.1 min·ng/mL 53.8 mL/min/kg
体内研究
(In Vivo)

CHNQD-02204 (2.5 mg/kg；静脉注射；给药 3 次) 可降低念珠菌病免疫缺陷小鼠脾脏、肺脏和肾脏中的真菌载量[1]。
CHNQD-02204 (2.5 mg/kg；静脉注射；每日 2 次；连续 3 天) 可降低播散性念珠菌病免疫功能低下小鼠的脾脏、肺脏和肾脏真菌负荷，并缓解感染诱导的体重下降[1]。
CHNQD-02204 (10 mg/kg；静脉注射；单次给药) 在健康雌性 C57BL/6J 小鼠中耐受性良好，7 天内未观察到死亡、体重变化或组织病理学异常[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR (female, 6-week-old, 24-26 g, immunocompromised via intraperitoneal cyclophosphamide injection)[1]
Dosage: 2.5 mg/kg
Administration: i.v.; three doses at 2, 6, and 10 h post-infection
Result: Reduced fungal burden in the spleen by 0.40 log10 CFU compared with the infected control group.
Reduced fungal burden in the lung by 0.29 log10 CFU compared with the infected control group.
Reduced fungal burden in the kidney by 0.62 log10 CFU compared with the infected control group.
Animal Model: ICR (female, 6-week-old, 24-26 g, immunocompromised via intraperitoneal cyclophosphamide injection)[1]
Dosage: 2.5 mg/kg
Administration: i.v.; twice daily; 3 consecutive days
Result: Reduced fungal burden in the spleen by 0.37 log10 CFU compared with the infected control group.
Reduced fungal burden in the lung by 0.78 log10 CFU compared with the infected control group.
Reduced fungal burden in the kidney by 0.41 log10 CFU compared with the infected control group.
Marked reduction of fungal content in multiple organs, with almost no fungal growth observed in the lungs via periodic acid-Schiff staining.
Mitigated weight loss induced by fungal infection during the 3-day treatment period.
分子量

517.31

Formula

C25H18Cl2O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CHNQD-02204 相关分类

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Keywords:

CHNQD-022043094676-22-6CHNQD02204CHNQD 02204FungalAspergillus candidusyeast-to-hypha morphological transitionsystemic candidiasisCandida albicansergosterolaspergillus fumigatus infectionmurine modelbiofilm formationC57BL/6J micecell membrane integrityInhibitorinhibitorinhibit

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目录号：
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