2. Apoptosis Anti-infection
  3. Caspase Apoptosis Parasite
  4. Diuvaretin

Diuvaretin 是一种抗疟剂、C-苯基化的 Dihydrochalcone。Diuvaretin 可从 U. acuminata 根部分离得到。Diuvaretin 可提高 Caspase-3 活性，触发细胞凋亡 (Apoptosis)。Diuvaretin 对恶性疟原虫具有抗寄生虫活性。Diuvaretin 可用于早幼粒细胞白血病和疟疾的研究。

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Diuvaretin

Diuvaretin Chemical Structure

CAS No. : 61463-04-5

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Diuvaretin 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Diuvaretin is an antimalarial agent and a C-phenylated dihydrochalcone. Diuvaretin can be isolated from the roots of U. acuminata. Diuvaretin increases the activity of Caspase-3 and triggers Apoptosis. Diuvaretin exhibits antiparasitic activity against Plasmodium falciparum. Diuvaretin can be used in the research of promyelocytic leukemia and malaria[1][2].

IC50 & Target[1][2]

Caspase-3

 

Plasmodium

 

体外研究
(In Vitro)

Diuvaretin (48 h) 可强效抑制早幼粒细胞白血病 HL-60 细胞的增殖，其 IC50 为 6.1 μM[1]。
Diuvaretin (10-20 μM; 24-48 h) 可诱导早幼粒细胞白血病 HL-60 细胞发生凋亡形态学改变 (染色质凝集及细胞核降解)[1]。
Diuvaretin (5-20 μM; 6-24 h) 可诱导早幼粒细胞白血病 HL-60 细胞出现 G1 期阻滞及亚 G1 峰形成，而 5 μM Diuvaretin 对细胞周期分布无影响[1]。
Diuvaretin 可抑制恶性疟原虫的生长，其 IC50 为 3.5 mg/mL[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Diuvaretin 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: human promyelocytic leukemia HL-60 cells
Concentration: dose-response
Incubation Time: 48 h
Result: Exhibited dose-dependent growth inhibition of HL-60 cells, with an IC50 value of 6.1 μM.
Showed stronger cytotoxicity than isouvaretin and slightly stronger cytotoxicity than uvaretin.

Cell Cycle Analysis[1]

Cell Line: human promyelocytic leukemia HL-60 cells
Concentration: 5 μM, 10 μM, 20 μM
Incubation Time: 6 h, 12 h, 24 h
Result: Induced accumulation of cells in the G1 phase and the appearance of a sub-G1 peak (indicative of apoptotic cells) at 10 μM or 20 μM for 12 h or 24 h.
Showed no cell cycle changes with 5 μM across 6-24 h incubation times.
分子量

484.55

Formula

C30H28O6
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Diuvaretin 相关分类

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Keywords:

Diuvaretin61463-04-5CaspaseApoptosisParasiteDNA fragmentationG1-phase cell cycle arrestHL-60 cellsKB cell cultureshuman promyelocytic leukemiaapoptosisnuclear degradationchromosomal condensationPlasmodium falciparumcaspase-3Inhibitorinhibitorinhibit

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