2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. DS-1055a

DS-1055a 是一种去岩藻糖基化的抗人 GARP 抗体。DS-1055a 可有效清除肿瘤微环境中 GARP 阳性的调节性 T 细胞，并激活效应 T 细胞。DS-1055a 具有抗肿瘤活性，可用于癌症 (如结肠癌) 的研究。

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DS-1055a

DS-1055a Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

DS-1055a 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DS-1055a is an afucosylated anti-human GARP antibody. DS-1055a effectively depletes GARP-positive regulatory T cells in the tumor microenvironment, and activates effector T cells. DS-1055a exhibits antitumor activity and can be used for the research of cancer, such as colon cancer[1].

反应种属

Human
体外研究
(In Vitro)

DS-1055a 可有效清除人源 GARP+ 调节性 T 细胞并激活人源效应 T 细胞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DS-1055a 相关抗体:
体内研究
(In Vivo)

DS-1055a 可降低结直肠癌人源化小鼠模型的肿瘤微环境中的 FOXP3+CD4+ T 细胞的数量，并展现出显著的抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
基因 ID

2615  [NCBI]

Accession

Q14392
靶点

GARP/LRRC32
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DS-1055a 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DS-1055aTransmembrane Glycoproteineffector T cellsGARPFOXP3+CD4+ T cellhuman peripheral blood mononuclear celltumor microenvironmentregulatory T cellsHT-29 tumorscancerhumanized mouse modelcolorectal cancerInhibitorinhibitorinhibit

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目录号：
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