2. Metabolic Enzyme/Protease
  3. PCSK9
  4. Enlicitide decanoate

Enlicitide (MK-0616) decanoate 是一种口服有效的大环肽类 PCSK9 抑制剂。Enlicitide decanoate 可与 PCSK9 结合，阻断其与低密度脂蛋白受体 (LDLR) 的相互作用，并增强肝脏对 LDL-C 的清除。Enlicitide decanoate 可降低致动脉粥样硬化脂蛋白，包括非 HDL 胆固醇、载脂蛋白 B 和脂蛋白 (a)。Enlicitide decanoate 可用于高胆固醇血症、杂合子家族性高胆固醇血症和动脉粥样硬化性心血管疾病的相关研究。

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Custom Peptide Synthesis

Enlicitide decanoate

Enlicitide decanoate Chemical Structure

CAS No. : 2861205-06-1

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Enlicitide decanoate 的其他形式现货产品:

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Other Forms of Enlicitide decanoate:

Enlicitide decanoate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Enlicitide (MK-0616) decanoate is an orally active macrocyclic peptide PCSK9 inhibitor. Enlicitide decanoate binds to PCSK9, blocks its interaction with low-density lipoprotein receptor (LDLR), and enhances hepatic clearance of LDL-C. Enlicitide decanoate reduces atherogenic lipoproteins, including non-HDL cholesterol, apolipoprotein B, and lipoprotein (a). Enlicitide decanoate is applicable to research related to hypercholesterolemia, heterozygous familial hypercholesterolemia, and atherosclerotic cardiovascular disease[1][2].

体外研究
(In Vitro)

Enlicitide decanoate 特异性结合 PCSK9 的 LDL 受体结合域，阻断 PCSK9 与 LDL 受体的相互作用，避免 PCSK9 降解肝细胞表面的 LDL 受体，从而增加肝细胞表面可用 LDL 受体数量，提升血液中低密度脂蛋白胆固醇 (LDL-C) 的肝脏清除效率，实现强效降脂[1][2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Enlicitide decanoate 相关抗体:
分子量

1722.09

Formula

C92H129FN14O17
CAS 号
Sequence

Ala-{Dpr}-Phe-Trp-Pro-Thr-Tyr-Pro(Covalent bridge:Phe3-Pro5,Ala1-Trp4,Trp4-Pro8,Ala1-Pro8,D-Dpr2)
Sequence Shortening

A-{Dpr}-FWPTYP(Covalent bridge:Phe3-Pro5,Ala1-Trp4,Trp4-Pro8,Ala1-Pro8,D-Dpr2)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Enlicitide decanoate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enlicitide decanoate2861205-06-1MK-0616 decanoatePCSK9Proprotein convertase subtilisin/kexin type 9atherosclerotic cardiovascular diseasehepatic LDL-C clearanceLDL receptorhypercholesterolemialipoprotein(a)apolipoprotein Bnon-HDL cholesterolheterozygous familial hypercholesterolemiaInhibitorinhibitorinhibit

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