2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Others
  3. Ferroptosis Reactive Oxygen Species (ROS) Drug Derivative
  4. Ferroptosis-IN-25

Ferroptosis-IN-25，Trolox (HY-101445) 衍生物，是一种选择性铁死亡 (ferroptosis) 抑制剂。Ferroptosis-IN-25 可通过清除活性氧 (ROS)、不依赖谷胱甘肽抑制脂质过氧化的方式，选择性抑制铁死亡。Ferroptosis-IN-25 可通过局部给药减轻小鼠角膜碱烧伤模型中的角膜新生血管形成与水肿。Ferroptosis-IN-25 可用于眼表疾病的研究。

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Ferroptosis-IN-25

Ferroptosis-IN-25 Chemical Structure

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Ferroptosis-IN-25 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ferroptosis-IN-25, Trolox (HY-101445) derivative, is a selective ferroptosis inhibitor. Ferroptosis-IN-25 selectively inhibits ferroptosis by scavenging ROS and suppressing lipid peroxidation independently of glutathion. Ferroptosis-IN-25 reduces corneal neovascularization and edema in murine corneal alkali burn models via topical administration.Ferroptosis-IN-25 can be used for the research of ocular surface diseases[1].

体外研究
(In Vitro)

Ferroptosis-IN-25 (Compound 20) (24 h) 可强效抑制 HT22 细胞中 RSL3 (HY-100218A) 诱导的铁死亡，其 IC50 为 0.036 μM[1]。
Ferroptosis-IN-25 (24 h) 在 HT22 细胞中表现出中度细胞毒性，其 TC50 为 45 μM，安全指数高达 1125[1]。
Ferroptosis-IN-25 (30 min) 在无细胞实验中表现出强效的 DPPH 自由基清除活性，其 EC50 为 5.4 μM[1]。
Ferroptosis-IN-25 在无细胞实验中过氧自由基淬灭能力较低，ORAC 值为 0.34 Trolox (HY-101445) 当量[1]。
Ferroptosis-IN-25 (24 h) 可强效抑制谷氨酸诱导的 HT22 细胞氧化死亡，其 IC50 为 0.15 μM[1]。
Ferroptosis-IN-25 (0.025-0.2 μM; 8 h) 可显著降低谷氨酸处理的 HT22 细胞内的 ROS 积累，但无法恢复被消耗的 GSH 水平[1]。
Ferroptosis-IN-25 (24 h) 可强效抑制 RSL3 诱导的人角膜上皮细胞 (HCECs) 铁死亡，其 IC50 为 0.052 μM[1]。
Ferroptosis-IN-25 (8 h) 可显著抑制 RSL3 诱导的人角膜内皮细胞 (HCECs) 脂质过氧化[1]。
Ferroptosis-IN-25 (24 h) 无法保护 HT-29 细胞免受 TSZ 诱导的坏死性凋亡，表明其相对于坏死性凋亡对铁死亡具有选择性活性[1]。
Ferroptosis-IN-25 (24 h) 无法保护人角膜内皮细胞 (HCECs) 免受 STS 诱导的细胞凋亡，表明其相对于细胞凋亡对铁死亡具有选择性活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ferroptosis-IN-25 相关抗体:

Immunofluorescence[1]

Cell Line: HT22 cells
Concentration: 0.025, 0.2 μM
Incubation Time: 8 h
Result: Reduced ROS levels.
体内研究
(In Vivo)

Ferroptosis-IN-25 (Compound 20) (50-800 μM；局部滴眼液；每日 2 次；连续 14 天) 可显著减轻碱烧伤诱导的角膜新生血管形成，减轻角膜水肿，并呈剂量依赖性恢复 C57BL/6 J 小鼠角膜上皮的 GPX4 表达[1]。
Ferroptosis-IN-25 (50-800 μM；局部滴眼液；每日 2 次；连续 14 天) 在健康 C57BL/6 J 小鼠中表现出良好的安全性，在有效治疗剂量下未观察到显著的角膜损伤或 IOP 变化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Alkali burn-induced corneal injury C57BL/6 J mice (7-week-old, 20-25 g)[1]
Dosage: 50 μM; 200 μM; 800 μM
Administration: topical eye drops; twice daily; 14 days
Result: Significantly attenuated corneal neovascularization (CNV) length at day 7 (200 μM dose).
Significantly reduced CNV length at day 14 (50 μM and 200 μM doses); lost efficacy at 800 μM dose.
Significantly reduced corneal edema (central corneal thickness) at day 14 (200 μM dose only).
Dose-dependently restored GPX4 expression in the corneal epithelium at day 14.
分子量

365.43

Formula

C21H23N3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ferroptosis-IN-25 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ferroptosis-IN-25FerroptosisReactive Oxygen Species (ROS)Drug DerivativeDrug derivativeHCECsHT22 cellsnecroptosisreactive oxygen speciesC57BL/6 J miceferroptosisapoptosislipid peroxidationHT-29 cellscorneal alkali burnInhibitorinhibitorinhibit

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