2. Gene
  3. NME6 - NME/NM23 nucleoside diphosphate kinase 6 Gene

NME6 - NME/NM23 nucleoside diphosphate kinase 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：NME/NM23 核苷二磷酸激酶 6

种属: Homo sapiens

同用名: NDK 6; NM23-H6; IPIA-ALPHA

基因 ID: 10201 | 基因类型: protein coding

关于 NME6

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,288,402-48,301,367 (from NCBI)

This gene has 22 transcripts (splice variants), 182 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 3.8), ovary (RPKM 2.8) and 25 other tissues.

功能概要

核苷二磷酸 (NDP) 激酶 (EC 2.7.4.6) ，例如 NME6，是一种普遍存在的酶，可通过磷酸组氨酸中间体在核苷和二氧核苷三磷酸和二磷酸之间催化 γ-磷酸转移 (Mehus 等人，1999 [PubMed] 10453732]) .[OMIM 提供，2010 年 7 月]

Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous Enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010]

NME6 基因产物(9)

mRNA Protein Name
NM_001308426.2 NP_001295355.1 nucleoside diphosphate kinase 6 isoform 2
NM_001308427.2 NP_001295356.1 nucleoside diphosphate kinase 6 isoform 2
NM_001308428.2 NP_001295357.1 nucleoside diphosphate kinase 6 isoform 2
NM_001308430.2 NP_001295359.1 nucleoside diphosphate kinase 6 isoform 3
NM_001308431.2 NP_001295360.1 nucleoside diphosphate kinase 6 isoform 4
NM_001308433.2 NP_001295362.1 nucleoside diphosphate kinase 6 isoform 4
NM_001308434.2 NP_001295363.1 nucleoside diphosphate kinase 6 isoform 5
NM_001308435.2 NP_001295364.1 nucleoside diphosphate kinase 6 isoform 6
NM_005793.5 NP_005784.1 nucleoside diphosphate kinase 6 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables nucleoside diphosphate kinase activity IDA
IDA: 通过直接分析推断
10618642 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21988832 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cell growth IDA
IDA: 通过直接分析推断
10618642 GOA
involved in negative regulation of mitotic nuclear division IDA
IDA: 通过直接分析推断
10618642 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
34789336 GOA
located in mitochondrial matrix IDA
IDA: 通过直接分析推断
34789336 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
10618642 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NME6 蛋白结构

NDK

NDK: Nucleoside diphosphate kinase (13 - 147)

  • 0
  • 100
  • 186 a.a.
蛋白主名 其他名称

nucleoside diphosphate kinase 6

NDP kinase 6

NME6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NME6 O75414 RCC1L Homo sapiens Q96I51
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Lymph Node Carcinoma

Lymph Node Cancer

Lymph Node Neoplasm

Neoplasm Of Lymph Node
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P10428 E6AP-mimicking peptide Inhibitor / 否
HY-RS09377 NME6 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus NME6 VGNC VGNC:32128
Felis catus NME6 VGNC VGNC:63836
Macaca mulatta NME6 VGNC VGNC:75222
Canis familiaris NME6 VGNC VGNC:43857
Rattus norvegicus NME6 RGD RGD:61896
Mus musculus NME6 MGD MGI:1861676
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