HYAL4 - hyaluronidase 4 Gene

中文名称：透明质酸酶 4

种属: Homo sapiens

同用名: CSHY; HYAL-4

关于 HYAL4

功能概要

该基因编码一种结构类似于透明质酸酶但缺乏透明质酸酶活性的蛋白质。编码的蛋白质充当硫酸软骨素特异性内切-β-N-乙酰半乳糖胺酶；也就是说，它对硫酸软骨素链表现出水解活性并将其降解为低聚糖。蛋白多糖是由硫酸软骨素链与蛋白质共价连接形成的。蛋白多糖是结缔组织细胞外基质中普遍存在的成分，也存在于许多细胞类型的表面，它们参与多种细胞过程，例如细胞增殖、分化、迁移、细胞间识别、细胞外基质沉积和组织形态发生。该基因在睾丸和胎盘中的表达最高。[RefSeq 提供，2019 年 4 月]

This gene encodes a protein which is similar in structure to hyaluronidases but lacks hyaluronidase activity. The encoded protein acts as a chondroitin-sulfate-specific endo-beta-N-acetylgalactosaminidase; that is, it exhibits hydrolytic activity toward chondroitin sulfate chains and degrades them into oligosaccharides. Proteoglycans are formed by the covalent linkage of chondroitin sulfate chains to protein. Proteoglycans are ubiquitous components of the extracellular matrix of connective tissues and are also found at the surface of many cell types where they participate in a variety of cellular processes such as cell proliferation, differentiation, migration, cell-cell recognition, extracellular matrix deposition, and tissue morphogenesis. The expression of this gene is highest in testes and placenta. [provided by RefSeq, Apr 2019]