2. Gene
  3. Psen1 - presenilin 1 Gene

Psen1 - presenilin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 29192 | 基因类型: protein coding

关于 Psen1

功能概要

Enables endopeptidase activity. Involved in several processes, including negative regulation of neuron apoptotic process; neural retina development; and proteolysis. Located in several cellular components, including cytoplasmic vesicle; lysosomal membrane; and sarcolemma. Part of protein-containing complex. Is integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease (multiple); Pick's disease; dilated cardiomyopathy 1U; frontotemporal dementia; and hidradenitis suppurativa. Orthologous to human PSEN1 (presenilin 1). [provided by Alliance of Genome Resources, Apr 2022]

Psen1 基因产物(1)

mRNA Protein Name
NM_019163.4 NP_062036.2 presenilin-1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables endopeptidase activity IDA
IDA: 通过直接分析推断
15456764 RGD
enables peptidase activity IDA
IDA: 通过直接分析推断
15456764 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
12297508 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cerebellum development IEP
IEP: 通过表达模式推断
16298244 RGD
involved in membrane protein ectodomain proteolysis IMP
IMP: 通过突变表型推断
17433308 RGD
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
11895366 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
11895366 RGD
involved in neural retina development IEP
IEP: 通过表达模式推断
12401445 RGD
involved in protein processing IDA
IDA: 通过直接分析推断
15456764 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
11570818 RGD
located in early endosome IDA
IDA: 通过直接分析推断
20126630 RGD
located in lysosomal membrane IDA
IDA: 通过直接分析推断
12736250 RGD
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
12099705 RGD
located in neuromuscular junction IDA
IDA: 通过直接分析推断
16595164 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
20126630 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
15456764 RGD
located in sarcolemma IDA
IDA: 通过直接分析推断
16595164 RGD
located in synaptic membrane IDA
IDA: 通过直接分析推断
20126630 RGD
located in synaptic vesicle IDA
IDA: 通过直接分析推断
20126630 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

presenilin-1

PS-1

相关产品

Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-14174 MRK-560 Inhibitor 99.0% 否
HY-W015515 L-Citronellol Inhibitor 99.92% 否
HY-P1378A β-Amyloid (1-43)(human) TFA 95.42% 否
HY-156011 PSEN1-IN-1 Inhibitor / 否
HY-156012 PSEN1-IN-2 Inhibitor / 否
HY-178128 PSEN1-IN-3 / 否
HY-180997 Aβ aggregation-IN-5 Inhibitor / 否
HY-P1378 β-Amyloid (1-43)(human) / 否
HY-RS11276 PSEN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18076 Psen1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24551 Psen1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Psen1 NCBI NCBI:5663
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