2. Gene
  3. Hdac1 - histone deacetylase 1 Gene

Hdac1 - histone deacetylase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：组蛋白脱乙酰酶 1

种属: Rattus norvegicus

基因 ID: 297893 | 基因类型: protein coding

关于 Hdac1

Primary_assembly 5: 141,853,989-141,881,111 reverse strand.mRatBN7.2:CM026978.1

This gene has 2 transcripts (splice variants), 189 orthologues, 12 paralogues and is associated with 30 phenotypes. Biased expression in Thymus (RPKM 374.), Adrenal (RPKM 298.9) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 DNA 结合转录因子结合活性；染色质结合活性；和组蛋白脱乙酰酶活性。参与多个过程，包括细胞因子产生的正调节；细胞凋亡过程的调节；蛋白质修饰过程的调控。位于几种细胞成分中，包括染色质；神经元投射；和细胞质的核周区。部分含蛋白质复合物。肺动脉高压的生物标志物。与人类 HDAC1（组蛋白脱乙酰酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription factor binding activity; chromatin binding activity; and histone deacetylase activity. Involved in several processes, including positive regulation of cytokine production; regulation of apoptotic process; and regulation of protein modification process. Located in several cellular components, including chromatin; neuron projection; and perinuclear region of cytoplasm. Part of protein-containing complex. Biomarker of pulmonary hypertension. Orthologous to human HDAC1 (histone deacetylase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hdac1 基因产物(1)

mRNA Protein Name
NM_001025409.1 NP_001020580.1 histone deacetylase 1

Hdac1 蛋白结构

HDAC1

HDAC1: cd10010 (3 - 373)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 482 a.a.
蛋白主名 其他名称

histone deacetylase 1

HD1

protein deacetylase HDAC1

protein decrotonylase HDAC1

相关产品

Approval
生物活性分子 (9)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10221 Vorinostat Inhibitor 99.96% 是
HY-10585 Valproic acid Inhibitor 99.19% 否
HY-15149 Romidepsin Inhibitor 99.98% 否
HY-10585A Valproic acid sodium Inhibitor 99.65% 否
HY-109015 Tucidinostat Inhibitor 98.60% 否
HY-12164 Mocetinostat Inhibitor 99.68% 是
HY-14842 Givinostat Inhibitor 98.67% 是
HY-13322 Pracinostat Inhibitor 99.80% 是
HY-10585B Valproic acid sodium (2:1) Inhibitor / 否
Clinical Phase
生物活性分子 (25)
目录号 产品名 作用方式
纯度 Phase
HY-14718A Resminostat hydrochloride Inhibitor 99.68% Phase 4
HY-12163 Entinostat Inhibitor 99.82% Phase 3
HY-50934 Tacedinaline Inhibitor 99.32% Phase 3
HY-13606 Dacinostat Inhibitor 98.45% Phase 3
HY-10990 Abexinostat Inhibitor 99.00% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 99.63% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Phase 3
HY-175513 ZWZH-21 Inhibitor / Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Phase 2
HY-100748 Zabadinostat Inhibitor 99.83% Phase 2
HY-153358 TNG260 Inhibitor 99.91% Phase 2
HY-13432 Nanatinostat Inhibitor 99.67% Phase 2
HY-101780 Tinostamustine Inhibitor 99.64% Phase 2
HY-16012A Domatinostat Inhibitor 99.34% Phase 2
HY-14718 Resminostat Inhibitor 99.84% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-13432A Nanatinostat TFA Inhibitor / Phase 2
HY-13216 Pyroxamide Inhibitor 99.54% Phase 1
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1
HY-16425 RG2833 Inhibitor 99.26% Phase 1
HY-15994 Citarinostat Inhibitor 98.66% Phase 1
HY-10226 JNJ-16241199 Inhibitor 99.05% Phase 1
Pre-clinical Phase
生物活性分子 (216)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13271A Tubastatin A Inhibitor 99.07% 否
HY-18998 LMK-235 Inhibitor 99.61% 否
HY-13428 Tubacin Inhibitor 99.54% 否
HY-15224 PCI-34051 Inhibitor 99.84% 否
HY-13271 Tubastatin A Hydrochloride Inhibitor 99.31% 否
HY-18613 CAY10603 Inhibitor 99.76% 否
HY-19327 ACY-738 Inhibitor 99.92% 否
HY-16699 Nexturastat A Inhibitor 98.28% 否
HY-144315 CYD19 Inhibitor 99.76% 否
HY-19618 BRD3308 Inhibitor 98.34% 否
HY-100719 BRD-6929 Inhibitor 99.01% 否
HY-N11692 9-Hydroxyoctadecanoic acid Inhibitor 98.0% 否
HY-19328 ACY-775 Inhibitor 99.71% 否
HY-111400 SR-4370 Inhibitor 98.38% 否
HY-119939 CHDI-390576 Inhibitor 98.10% 否
HY-104008 ACY-957 Inhibitor 99.63% 否
HY-123295 HDAC3-IN-T247 Inhibitor 98.91% 否
HY-18976 UF010 99.83% 否
HY-115475 SW-100 Inhibitor 99.93% 否
HY-19348 Pimelic Diphenylamide 106 Inhibitor 98.54% 否
HY-114414 HDACs/mTOR Inhibitor 1 Inhibitor 99.01% 否
HY-126330 SS-208 Inhibitor 99.00% 否
HY-116818 Crebinostat Inhibitor 99.79% 否
HY-10585R Valproic acid (Standard) Inhibitor 99.97% 否
HY-W009776 Suberoyl bis-hydroxamic acid Inhibitor 98.0% 否
HY-19747 HPOB Inhibitor 99.54% 否
HY-152134 HDAC6 degrader-3 Degrader 98.60% 否
HY-18712 BG45 Inhibitor 99.95% 否
HY-102083 BRD4884 Inhibitor 99.0% 否
HY-146346 HD-TAC7 Inhibitor 98.75% 否
HY-N2150 Psammaplin A Inhibitor 96.0% 否
HY-100871 WT-161 Inhibitor 98.36% 否
HY-114303 CM-675 Inhibitor 99.53% 否
HY-124053 BRD2492 Inhibitor 99.18% 否
HY-164782 PT3 Inhibitor 99.94% 否
HY-158075 DNMT/HDAC-IN-1 Inhibitor 99.87% 否
HY-161464 Chlopynostat Inhibitor 98.36% 否
HY-135714 Bavarostat Inhibitor 99.51% 否
HY-124295 Imofinostat Inhibitor 99.40% 否
HY-100384 NKL 22 Inhibitor 97.26% 否
HY-12954 PTACH Inhibitor 99.65% 否
HY-162361 HDAC1-IN-7 Inhibitor 99.97% 否
HY-170495 HDAC6 degrader-5 Inhibitor 99.55% 否
HY-130538 1-Naphthohydroxamic acid Inhibitor 99.59% 否
HY-150109 Purinostat mesylate Inhibitor 99.45% 否
HY-110280 MC1742 Inhibitor 98.95% 否
HY-142690A HDAC-IN-27 dihydrochloride Inhibitor ≥99.0% 否
HY-156422 KPZ560 Inhibitor 99.72% 否
HY-150109A Purinostat Inhibitor / 否
HY-124337 BG48 Inhibitor / 否
HY-117583 cis-BG47 Inhibitor 98.02% 否
HY-162616 SelSA Inhibitor 99.83% 否
HY-130493 HPB Inhibitor 99.11% 否
HY-124782 HDAC8-IN-8 Inhibitor 99.01% 否
HY-131708A FNDR-20123 Inhibitor 98.08% 否
HY-19754A CRA-026440 hydrochloride Inhibitor 98.12% 否
HY-151261 HDAC6-IN-13 Inhibitor 98.08% 否
HY-117554 BRD9757 Inhibitor 99.75% 否
HY-149208 HDAC-IN-53 Inhibitor 95.73% 否
HY-141427 MOCPAC 99.64% 否
HY-152174 HDAC-IN-52 Inhibitor 99.46% 否
HY-109015S Tucidinostat-d4 Inhibitor 98.63% 否
HY-131708 FNDR-20123 free base Inhibitor / 否
HY-146678 HDAC6-IN-5 Inhibitor / 否
HY-128582 PI3K/HDAC-IN-1 Inhibitor / 否
HY-151464 SHP2/HDAC-IN-1 Inhibitor / 否
HY-143497 HDAC1/2 and CDK2-IN-1 Inhibitor / 否
HY-146679 HDAC6-IN-6 Inhibitor / 否
HY-168088 DNMT1/HDAC-IN-1 Inhibitor / 否
HY-168650 ROCK/HDAC-IN-1 Inhibitor / 否
HY-169405 AAK1/HDACs-IN-1 Inhibitor / 否
HY-161778 ZG-126 Inhibitor / 否
HY-174401 PROTAC HDAC6 degrader 5 Inhibitor / 否
HY-161350 ALK/HDAC-IN-1 Inhibitor / 否
HY-163368 HDAC6-IN-34 Inhibitor / 否
HY-149578 Tubulin/HDAC-IN-3 Inhibitor / 否
HY-146684 HDAC-IN-36 Inhibitor / 否
HY-163090 HR488B Inhibitor / 否
HY-170966 HDAC1-IN-9 Inhibitor / 否
HY-145852 Top/HDAC-IN-2 Inhibitor / 否
HY-151569 SAHA-OH Inhibitor / 否
HY-159172 HDAC3-IN-4 Inhibitor / 否
HY-143462 c-Met/HDAC-IN-2 Inhibitor / 否
HY-162630 HDAC6-IN-44 Inhibitor / 否
HY-150595 HDAC6-IN-10 Inhibitor / 否
HY-125645 M122 Inhibitor / 否
HY-149946 HDAC-IN-57 Inhibitor / 否
HY-147892 HDAC-IN-42 Inhibitor / 否
HY-147731 HDAC6-IN-9 Inhibitor / 否
HY-163430 HDAC-IN-71 Inhibitor / 否
HY-176733 HDAC6-IN-61 Inhibitor / 否
HY-147991 PDE5/HDAC-IN-1 Inhibitor / 否
HY-162487 HDAC-IN-72 Inhibitor / 否
HY-146750 HDAC-IN-37 Inhibitor / 否
HY-168502 HDAC-IN-81 Inhibitor / 否
HY-152226 MC2590 Inhibitor 98.71% 否
HY-151443 HDAC-IN-47 Inhibitor / 否
HY-151364 HDAC6/8/BRPF1-IN-1 Inhibitor / 否
HY-150004 c-Met/HDAC-IN-3 Inhibitor / 否
HY-178333 HDAC6-IN-66 Inhibitor / 否
HY-144293 HDAC-IN-31 Inhibitor / 否
HY-142690 HDAC-IN-27 Inhibitor / 否
HY-143877 NN-390 Inhibitor / 否
HY-178948 HDAC10-IN-3 Inhibitor / 否
HY-157481 HDAC1-IN-6 Inhibitor / 否
HY-152133 PROTAC HDAC6 degrader 1 Degrader / 否
HY-147966 HDAC-IN-43 Inhibitor / 否
HY-178161 HDAC degrader-2 Degrader / 否
HY-154855 HDAC-IN-56 Inhibitor / 否
HY-169439 Temozolomide-amino hydrochloride / 否
HY-162910 HDAC-IN-79 Inhibitor / 否
HY-163282 NB512 Inhibitor / 否
HY-146392 HDAC-IN-39 Inhibitor / 否
HY-176868 Rodin-C Inhibitor / 否
HY-175671 LSD1/HDAC-IN-3 Inhibitor / 否
HY-168477 HDAC1-IN-8 Inhibitor / 否
HY-173520 EGFR/HDAC-IN-1 Inhibitor / 否
HY-162955 LSD1/HDAC-IN-1 Inhibitor / 否
HY-144292 HDAC-IN-30 Inhibitor / 否
HY-147934 HDAC8-IN-3 Inhibitor / 否
HY-176561 IOR-160 Inhibitor / 否
HY-124946 C1A Inhibitor / 否
HY-161155 HDAC6-IN-31 Inhibitor / 否
HY-162781 HDAC1/6-IN-2 Inhibitor / 否
HY-174398 GSK-3β/HDAC-IN-2 Inhibitor / 否
HY-172359 PROTAC HDAC6 degrader 4 Degrader / 否
HY-176904 JPS004 Degrader / 否
HY-163535 J208 Inhibitor / 否
HY-145845 HDAC1/MAO-B-IN-1 Inhibitor / 否
HY-144098 HDAC8-IN-2 Inhibitor / 否
HY-162319 Tubulin/HDAC-IN-4 Inhibitor / 否
HY-151263 G4/HDAC-IN-1 Inhibitor / 否
HY-144395 HDAC6-IN-4 Inhibitor / 否
HY-161524 HDAC6-IN-43 Inhibitor / 否
HY-174149 HDAC6-IN-59 Inhibitor / 否
HY-150774 HDAC6/HSP90-IN-2 Inhibitor / 否
HY-15144B (S)-Trichostatin A Inhibitor / 否
HY-144725 HDAC1/6-IN-1 Inhibitor / 否
HY-178485 SJY26 Inhibitor / 否
HY-149283 JAK/HDAC-IN-2 Inhibitor / 否
HY-163503 HDAC6-IN-38 Inhibitor / 否
HY-146159 PI3K/HDAC-IN-2 Inhibitor / 否
HY-162330 HDAC6-IN-36 Inhibitor / 否
HY-117374 HDAC3-IN-1 Inhibitor / 否
HY-163803 CM-444 Inhibitor / 否
HY-161783 HDAC6-IN-45 Inhibitor / 否
HY-172878 HDAC/PSMD14-IN-1 Inhibitor / 否
HY-144297 HDAC1-IN-3 Inhibitor / 否
HY-152173 HDAC-IN-51 Inhibitor / 否
HY-173330 HDAC-IN-89 Inhibitor / 否
HY-141701 mTOR/HDAC-IN-1 Inhibitor / 否
HY-178022 HDAC6-IN-63 Inhibitor / 否
HY-157740 XSJ-10 Inhibitor / 否
HY-126566 Trichostatin C Inhibitor / 否
HY-168962 HDAC-IN-88 Inhibitor / 否
HY-162769 HDAC3-IN-5 Inhibitor / 否
HY-172889 PI3K/HDAC-IN-4 Inhibitor / 否
HY-163834 HDAC6-IN-47 Inhibitor / 否
HY-115941 HDAC-IN-9 Inhibitor / 否
HY-150597 HDAC-IN-46 Inhibitor / 否
HY-143241 HDAC-IN-34 Inhibitor / 否
HY-161868 DLC-50 Inhibitor / 否
HY-163894 HDAC6-IN-48 Inhibitor / 否
HY-161688 HDAC-IN-73 Inhibitor / 否
HY-163207 sEH/HDAC6-IN-1 Inhibitor / 否
HY-172200 PD-L1/HDAC6-IN-1 Inhibitor / 否
HY-162678 HDAC-IN-75 Inhibitor / 否
HY-152146 HDAC-IN-50 Inhibitor / 否
HY-158371 HDAC/CK2-IN-1 Inhibitor / 否
HY-151248 HDAC2-IN-1 Inhibitor / 否
HY-178021 HDAC1-IN-11 Inhibitor / 否
HY-156444 HDAC1/CDK7-IN-1 Inhibitor / 否
HY-170379 HDAC-IN-84 Inhibitor / 否
HY-146539 HDAC-IN-35 Inhibitor / 否
HY-161984 HDAC-IN-76 Inhibitor / 否
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / 否
HY-172891 CDK9/HDAC1/HDAC3-IN-1 Inhibitor / 否
HY-169156 HDAC6-IN-49 Inhibitor / 否
HY-175021 HDAC-IN-91 Inhibitor / 否
HY-146351 HDAC-IN-38 Inhibitor / 否
HY-147840 HDAC-IN-41 Inhibitor / 否
HY-149029 TH-6 Inhibitor 95.00% 否
HY-151153 HDAC1-IN-5 Inhibitor / 否
HY-144332 PHD2/HDACs-IN-1 Inhibitor / 否
HY-133147 HDAC3/6-IN-2 Inhibitor / 否
HY-172159 FF2039 Inhibitor / 否
HY-144654 HDAC/Top-IN-1 Inhibitor / 否
HY-175030 TNI-97 Inhibitor / 否
HY-175176 HDAC1/6-IN-3 Inhibitor / 否
HY-159171 sEH/HDAC6-IN-2 Inhibitor / 否
HY-174449 HDAC6-IN-62 Inhibitor / 否
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / 否
HY-150503 KH-259 Inhibitor / 否
HY-150577 HDAC-IN-45 Inhibitor / 否
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / 否
HY-152225 MC2625 Inhibitor / 否
HY-151897 HDAC-IN-49 Inhibitor / 否
HY-157385 HDAC-IN-67 Inhibitor / 否
HY-178023 HDAC6-IN-64 Inhibitor / 否
HY-169938 LSD1/HDAC-IN-2 Inhibitor / 否
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / 否
HY-172133 HDAC3-IN-6 Inhibitor / 否
HY-169400 HDACs/EZH2-IN-1 Inhibitor / 否
HY-173064 DS-103 Inhibitor / 否
HY-169433 Naph-Se-TMZ Inhibitor / 否
HY-162658 Leuxinostat Inhibitor / 否
HY-151896 HDAC6-IN-14 Inhibitor / 否
HY-12487 NL-103 Inhibitor / 否
HY-146276 CDK/HDAC-IN-2 Inhibitor / 否
HY-146293 HDAC6/HSP90-IN-1 Inhibitor / 否
HY-155222 TW9 Inhibitor / 否
HY-117583A BG47 Inhibitor / 否
HY-148624 CHDI-00484077 Inhibitor / 否
HY-119316A CM-545 Inhibitor / 否
HY-19754 CRA-026440 Inhibitor / 否
HY-112147 IDO1 and HDAC1 Inhibitor Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hdac1 NCBI NCBI:3065
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