NOL6 - nucleolar protein 6 Gene

中文名称：核仁蛋白 6

种属: Homo sapiens

同用名: NRAP; UTP22; bA311H10.1

基因 ID: 65083 | 基因类型: protein coding

关于 NOL6

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:33,461,353-33,473,924 (from NCBI)

Ubiquitous expression in testis (RPKM 9.6), skin (RPKM 6.9) and 25 other tissues.

功能概要

核仁是一种致密的亚核无膜细胞器，聚集在 rRNA 基因簇周围，并在核糖体生物合成中发挥作用。该基因编码一种在物种间高度保守的核仁 RNA 相关蛋白。透化细胞的 RNase 处理表明核仁定位是 RNA 依赖性的。进一步的研究表明，该蛋白质通过与前 rRNA 初级转录本的相互作用与核糖体生物发生相关。已在该位点观察到选择性剪接，并且已鉴定出编码不同亚型的两个剪接变体。[RefSeq 提供，2008 年 7 月]

The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

NOL6 基因产物(2)

mRNA	Protein	Name
NM_022917.5	NP_075068.2	nucleolar protein 6 isoform alpha
NM_139235.4	NP_631981.2	nucleolar protein 6 isoform gamma

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ribosomal small subunit biogenesis	IDA IDA: 通过直接分析推断	34516797	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of small-subunit processome	IDA IDA: 通过直接分析推断	34516797	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NOL6 蛋白结构

Nrap

0
200
400
600
800
1000
1146 a.a.

蛋白主名

其他名称

nucleolar protein 6

nucleolar RNA-associated protein

NOL6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NOL6	Q9H6R4	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
种属内	NOL6	Q9H6R4	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
种属内	NOL6	Q9H6R4	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09416	NOL6 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	NOL6	MGD	MGI:2140151
Canis familiaris	NOL6	VGNC	VGNC:43883
Bos taurus	NOL6	VGNC	VGNC:32158
Macaca mulatta	NOL6	VGNC	VGNC:75218
Rattus norvegicus	NOL6	RGD	RGD:1308033
Felis catus	NOL6	VGNC	VGNC:63852

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

粤ICP备2021105330号-3

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NOL6 - nucleolar protein 6 Gene

关于 NOL6

功能概要

NOL6 基因产物(2)

NOL6 蛋白结构

NOL6 蛋白互作信息

关联疾病

直系同源

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NOL6 - nucleolar protein 6 Gene

关于 NOL6

功能概要

NOL6 基因产物(2)

NOL6 蛋白结构

NOL6 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z