2. Others Apoptosis Autophagy
  3. Fluorescent Dye Apoptosis Autophagy
  4. HJTA

HJTA 是一种选择性的、pH/GSH 双响应荧光探针 (Fluorescent probe) 和抗癌剂。HJTA 选择性地与 GSTπ 发生酶促反应。HJTA 通过调节凋亡和自噬蛋白的表达，诱导凋亡 (Apoptosis) 和自噬 (Autophagy)。HJTA 在肿瘤细胞中表现出 pH 和 GSH 双重响应性荧光。HJTA 选择性地照亮肿瘤组织，实现原位结肠肿瘤的精确可视化。HJTA 对结肠癌具有抗癌作用。HJTA 可用于结肠癌的研究。

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HJTA

HJTA Chemical Structure

CAS No. : 2442502-32-9

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HJTA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HJTA is a selective, pH/GSH dual-responsive Fluorescent probe and anticancer agent. HJTA selectively undergoes an enzymatic reaction with GSTπ. HJTA induces Apoptosis and Autophagy by regulating the expression of apoptotic and autophagic proteins. HJTA exhibits pH- and GSH-dual-responsive fluorescence in tumor cells. HJTA selectively illuminates tumor tissues, enabling precise in situ visualization of colon tumors. HJTA exerts anticancer effects against colon cancer. HJTA can be used for colon cancer research[1].

体外研究
(In Vitro)

HJTA 可强效抑制 HT29、HepG2 和 9L-2 癌细胞的增殖[1]。
HJTA (0.4-2.5 μM；72 h) 以剂量依赖方式诱导结肠癌 HT29 细胞发生凋亡，其作用机制为上调 Bax、下调 Bcl-2 并激活 caspase-3 与 PARP[1]。
HJTA (0.4-2.5 μM) 以剂量依赖方式诱导结肠癌细胞 HT29 发生自噬，表现为 LC3-II 和 Beclin-1 水平升高、p62 水平降低，且 LC3-II/LC3-I 比值上升[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HJTA 相关抗体:

Apoptosis Analysis[1]

Cell Line: HT29 human colon cancer cells
Concentration: 0.4-2.5 μM
Incubation Time: 72 h
Result: Induced apoptotic cell percentages of 36.8% (1.0 μM), and 52.3% (2.5 μM).
Increased pro-apoptotic Bax levels dose-dependently.
Decreased anti-apoptotic Bcl-2 levels dose-dependently.
Increased levels of cleaved caspase-3 and cleaved PARP dose-dependently.
体内研究
(In Vivo)

HJTA (腹腔注射；每日一次；连续 21 天，20-40 mg/kg) 可在体内对结肠癌异种移植物的生长发挥强效抑制作用，其中 40 mg/kg (腹腔注射，每日一次，连续 21 天) 剂量组的肿瘤重量较对照组降低 67.7%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude (female, 5−6 weeks old)[1]
Dosage: 20 mg/kg; 40 mg/kg
Administration: i.p.; daily; 21 days
Result: Reduced mean tumor weight by 67.7% (40 mg/kg group) relative to the control group.
Significantly reduced tumor volume growth over the 21-day period relative to the control group, with the 40 mg/kg dose showing greater tumor growth inhibition than the 20 mg/kg dose.
Showed no significant changes in body weight between HJTA-treated groups and the control group.
Animal Model: ICR (female)[1]
Dosage: 240.0 mg/kg; 300.0 mg/kg; 375.0 mg/kg; 468.8 mg/kg; 585.9 mg/kg
Administration: i.p.; single dose
Result: Achieved 100% survival over 14 days with no abnormalities in body weight, eating, drinking, or activity in the 240.0 mg/kg and 300.0 mg/kg groups.
Achieved 80% survival with 2 deaths occurring by day 4 in the 375.0 mg/kg group.
Achieved 40% survival with 6 deaths occurring by day 4 in the 468.8 mg/kg group.
Achieved 10% survival with 9 deaths occurring by day 14 in the 585.9 mg/kg group.
Had a calculated median lethal dose (LD50) of 475 mg/kg.
分子量

501.53

Formula

C28H27N3O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HJTA 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HJTA2442502-32-9Fluorescent DyeApoptosisAutophagyglutathioneapoptotic proteinautophagic proteincancer cell apoptosiscancer cell autophagyorthotopic colonic tumor tissueHT29 human colon cancer cellsCCD841 normal intestinal cellscolonic cancerGSTπInhibitorinhibitorinhibit

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