2. NF-κB Autophagy
  3. IKK Autophagy
  4. IKKε-IN-1

IKKε-IN-1 是一种 IKKε 抑制剂。IKKε-IN-1 降低细胞活力、抑制集落形成和细胞迁移。IKKε-IN-1 诱导癌细胞自噬 (Autophagy)。IKKε-IN-1 可用于结直肠癌、肝细胞癌、膀胱癌、乳腺癌、肺癌、宫颈癌等癌症的研究。

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IKKε-IN-1

IKKε-IN-1 Chemical Structure

CAS No. : 3035441-37-0

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IKKε-IN-1 相关抗体

Top Publications Citing Use of Products

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IKK-α IKK-β IKK IKKε TBK1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IKKε-IN-1 is a IKKε inhibitor. IKKε-IN-1 reduces cell viability, inhibits colony formation and cell migration. IKKε-IN-1 induces autophagy (Autophagy) in cancer cells. IKKε-IN-1 can be used in the research of cancers including colorectal cancer, hepatocellular carcinoma, bladder cancer, breast cancer, lung cancer, and cervical cancer[1].

IC50 & Target

IKKε

 

体外研究
(In Vitro)

IKKε-IN-1 (6.25-50 μM; 72 h) 降低 HCT116、HepG2、T24、MDA-MB-231、A549、Hela 细胞的存活率，其中对 HCT116 结直肠癌细胞的活性最强 (IC50 = 13.37 μM)[1]。
IKKε-IN-1 (6.25-50 μM; 2-14 days) 抑制 HCT116 和 HepG2 细胞的长期增殖能力，减少了 HCT116 细胞的迁移[1]。
IKKε-IN-1 (12.5-50 μM; 48 h) 可在 HCT116 细胞中诱导自噬体形成但阻断自噬流[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IKKε-IN-1 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HCT116、HepG2、T24、MDA-MB-231、A549、Hela cells
Concentration: 6.25、12.5、25、50 μM
Incubation Time: 72 h
Result: Reduced cell viability in all six cancer cell lines in a concentration-dependent manner.
Exhibited IC50 values of 13.37 μM (HCT116), 17.44 μM (HepG2), 29.733 μM (T24), 32.48 μM (MDA-MB-231), 66.3 μM (A549), and 68.05 μM (HeLa).

Cell Proliferation Assay[1]

Cell Line: HCT116, HepG2 cells
Concentration: 12.5、25、50 μM
Incubation Time: 14 days
Result: Reduced colony formation in both cell lines in a concentration-dependent manner.

Cell Migration Assay [1]

Cell Line: HCT116 cells
Concentration: 6.25、12.5 μM
Incubation Time: 48 h
Result: Inhibited the migration, had a more pronounced effect on reducing
cell migration at 12.5 μM.

Cell Autophagy Assay[1]

Cell Line: HCT116 cells
Concentration: 12.5、25、50 μM
Incubation Time: 48 h
Result: Increased the LC3B-II/LC3B-I ratio in a concentration-dependent manner, indicating increased autophagosome formation, and also increased p62 levels in a concentration-dependent manner, indicating blocked autophagic flux.
Significantly increased the number of yellow autophagosome puncta, confirming impaired fusion of autophagosomes and lysosomes.
分子量

416.51

Formula

C26H28N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IKKε-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IKKε-IN-13035441-37-0IKKAutophagyIκB kinaseI kappa B kinaseIKKε inhibitorcolorectal cancerhepatocellular carcinomabladder cancerbreast cancerlung cancercervical cancerInhibitorinhibitorinhibit

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