2. Metabolic Enzyme/Protease Anti-infection Others
  3. HIF/HIF Prolyl-Hydroxylase EBV Drug Intermediate
  4. mCPX

mCPX 是抗真菌剂 Ciclopirox olamine (CPX) (HY-B0450A) 的前药，CPX 具有抑菌和铁螯合能力，而 mCPX 能提高 CPX 对铁的稳定性。mCPX 继承了 CPX 的核心机制路径，可由缺氧通路 (HIF‑1α)​ 在 EBV+ 胃癌细胞中诱导 EBV 裂解再激活。mCPX 可用于 EBV 阳性胃癌的相关研究。

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mCPX

mCPX Chemical Structure

CAS No. : 1351572-56-9

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mCPX 相关抗体

Top Publications Citing Use of Products

查看 HIF/HIF Prolyl-Hydroxylase 亚型特异性产品:

查看所有亚型
HIF-1α HIF

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

mCPX is a prodrug of the antifungal agent Ciclopirox olamine (CPX) (HY-B0450A). CPX exhibits bacteriostatic and iron-chelating activities, while mCPX enhances the iron stability of CPX. mCPX inherits the core mechanism pathway of CPX and can induce EBV lytic reactivation in EBV+ gastric cancer cells via the hypoxia pathway (HIF‑1α). mCPX is applicable to research related to EBV-positive gastric cancer[1].

体外研究
(In Vitro)

mCPX 可在 SNU719 和 AGSBX1 EBV+ 胃癌细胞系中诱导 EBV 裂解周期，其活性与 CPX 相当，且对铁介导的失活具有显著更强的抗性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

mCPX 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route T1/2 Tmax Cmax AUC AUC0-∞ MRT Vd CL
Rat[1] 14 mg/kg i.p. 10.88 h 0.67 h 3085.04 μg/L 9195.38 μg/L·h 9455.28 μg/L·h 6.67 h 23.25 L/kg 1.48 L/h/kg
Rat[1] 14 mg/kg i.g. 5.01 h 1.50 h 511.88 μg/L 4332.53 μg/L·h 4350.86 μg/L·h 6.05 h 23.25 L/kg 3.22 L/h/kg
体内研究
(In Vivo)

mCPX 在 SNU719 异种移植小鼠模型中，其体内抗肿瘤活性优于 CPX[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

249.31

Formula

C14H19NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

mCPX 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mCPX1351572-56-9HIF/HIF Prolyl-HydroxylaseEBVDrug IntermediateHypoxia-inducible factorsHIFsHIF-PHEpstein-Barr VirusDrug IintermediateEBV+ gastric cancer cellsepstein-barr virus+ gastric cancerEBV lytic cycleSNU719EBV lytic reactivationAGSBX1Inhibitorinhibitorinhibit

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目录号：
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