2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. Moreollic acid

Moreollic acid 是一种 PTP1B 抑制剂，对人源靶点的 IC50 为 4.44 μM，Ki 为 1.75 μM。Moreollic acid 可阻断细胞周期从 G1 期向 S 期进展，抑制肿瘤细胞增殖。Moreollic acid 可用于 2 型糖尿病、肥胖症、结肠癌等癌症的相关研究。

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Moreollic acid

Moreollic acid Chemical Structure

CAS No. : 173792-68-2

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Moreollic acid 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Moreollic acid is a PTP1B inhibitor, with an IC50 of 4.44 μM and a Ki of 1.75 μM against human targets. Moreollic acid blocks cell cycle progression from the G1 to S phase and inhibits tumor cell proliferation. Moreollic acid can be used in research related to type 2 diabetes, obesity, colon cancer and other cancers[1][2].

体外研究
(In Vitro)

Moreollic acid (Compound 2) (5 μM; 48 h) 可强效抑制 HCT116 人结肠癌细胞活力，抑制率达 83.86%，而对 A549、MDA-MB-231 和 KYSE30 癌细胞活力仅表现出弱抑制或无抑制作用[2]。
Moreollic acid (48 h) 可抑制 HCT116、DLD1 和 SW620 人结肠癌细胞的活力，其 IC50 值分别为 1.71 μM、1.44 μM 和 1.49 μM；而针对正常 NCM460 结肠上皮细胞，其 IC50 值更高，为 3.16 μM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Moreollic acid 相关抗体:

Cell Viability Assay[2]

Cell Line: A549, MDA-MB-231, KYSE30, HCT116
Concentration: 5 μM
Incubation Time: 48 h
Result: Inhibited HCT116 cell viability by 83.86%.
Showed minimal inhibition of A549 cell viability by 18.38%.
Showed minimal inhibition of MDA-MB-231 cell viability by -4.9%.
Showed minimal inhibition of KYSE30 cell viability by 20.76%.
分子量

592.68

Formula

C34H40O9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Moreollic acid 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Moreollic acid173792-68-2PhosphataseKYSE30Protein tyrosine phosphatase 1BA549PTP1BMDA-MB-231cancertype 2 diabetesHCT116 human colon cancer cellcolon cancerobesityInhibitorinhibitorinhibit

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