2. Anti-infection
  3. Bacterial
  4. MSU-43557

MSU-43557 是靶向脓肿分枝杆菌 (Mycobacterium abscessus) 中 MmpL3 的抑制剂和抗菌剂，具有真核细胞毒性低、抗菌谱窄且仅针对分枝杆菌、耐药频率低。MSU-43557 通过抑制 MmpL3 功能降低海藻糖二分枝酸酯水平，破坏生物膜形成并降低相关细菌活力，同时对细胞内脓肿分枝杆菌具有杀菌作用。MSU-43557 与抗生素具有相加或协同效应，可用于脓肿分枝杆菌的多重耐药分离株及感染的研究。

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MSU-43557

MSU-43557 Chemical Structure

CAS No. : 2919699-59-3

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MSU-43557 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MSU-43557 is a Mycobacterium abscessus MmpL3 (MAB_4508) inhibitor and bactericidal agent. MSU-43557 inhibits MmpL3 function, disrupts trehalose monomycolate synthesis, and reduces biofilm-associated Mycobacterium abscessus viability. MSU-43557 exerts bactericidal activity against intracellular Mycobacterium abscessus. MSU-43557 shows low eukaryotic cytotoxicity and low Mycobacterium abscessus resistance frequency. MSU-43557 can be used for the research of mycobacterium abscessus infection[1].

体外研究
(In Vitro)

MSU-43557 (80 μM-0.08 nM；3 d) 可在体外强效抑制 Mycobacterium abscessus ATCC 19977 的生长，且在 5× MIC 浓度下呈现时间依赖性杀菌活性；同时，MSU-43557 可强效抑制结核分枝杆菌菌株、脓肿分枝杆菌和耻垢分枝杆菌，在 80 μM 内对非分枝杆菌无活性，且对多重耐药脓肿分枝杆菌临床分离株表现出可变的抑菌活性[1]。
MSU-43557 (0.18 nM-160 μM; 3 d) 可破坏成熟的 Mycobacterium abscessus 生物膜，其 EC50 为 8.66 μM；同时可降低生物膜内的细菌活力，对应 EC50 为 0.16 μM[1]。
MSU-43557 (0.18 nM-160 μM; 3 d) 可在小鼠骨髓来源巨噬细胞中杀灭细胞内的 Mycobacterium abscessus ATCC 19977，其 EC50 为 0.39 μM，并对小鼠骨髓来源巨噬细胞表现出低细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MSU-43557 相关抗体:

Cell Viability Assay[1]

Cell Line: Mycobacterium tuberculosis strains, Mycobacterium abscessus, and Mycobacterium smegma
Concentration: 80 μM-0.08 nM
Incubation Time: 3 d
Result: Inhibited the growth of Mycobacterium abscessus ATCC 19977 by an EC50 of 1.29 μM and a MIC of 3.69 μM.
Effectively inhibited Mycobacterium tuberculosis strains (EC50 value of 0.13 to 0.19 μM), Mycobacterium abscessus (EC50 of 1.82 μM), and Mycobacterium smegma (EC50 of 2.54 μM).

Cell Cytotoxicity Assay[1]

Cell Line: Murine bone marrow-derived macrophages (BMMΦ)
Concentration: 200 to 0.13 μM
Incubation Time: 3 d
Result: Resulted in a CC50 of >80 μM, indicating low cytotoxicity relative to intracellular efficacy.
分子量

326.22

Formula

C15H17Cl2N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MSU-43557 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

MSU-435572919699-59-3MSU43557MSU 43557BacterialMycobacterium abscessus ATCC 19977mycolic acid transportMycobacterium abscessus mmpL3 mutantsbiofilm-associated Mycobacterium abscessusMmpL3murine bone marrow-derived macrophagesMAB_4508Mycobacterium abscessusintracellular Mycobacterium abscessustrehalose monomycolate synthesisInhibitorinhibitorinhibit

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