2. Anti-infection
  3. Bacterial
  4. MSU-44147

MSU-44147 是靶向脓肿分枝杆菌 (Mycobacterium abscessus) 中 MmpL3 的抑制剂和抗菌剂，具有真核细胞毒性低、抗菌谱窄且仅针对分枝杆菌、耐药频率低。MSU-44147 通过抑制 MmpL3 功能降低海藻糖二分枝酸酯水平，破坏生物膜形成并降低相关细菌活力，同时对细胞内脓肿分枝杆菌具有杀菌作用。MSU-44147 与抗生素具有相加或协同效应，可用于脓肿分枝杆菌的多重耐药分离株及感染的研究。

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MSU-44147

MSU-44147 Chemical Structure

CAS No. : 3105177-29-2

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MSU-44147 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MSU-44147 is an inhibitor and antimicrobial agent targeting MmpL3 in Mycobacterium abscessus, with low eukaryotic cytotoxicity, a narrow antimicrobial spectrum that is specific only to mycobacteria, and low drug resistance frequency. MSU-44147 reduces trehalose dimycolate levels by inhibiting MmpL3 function, disrupts biofilm formation and reduces the viability of related bacteria, while exerting bactericidal effects on intracellular Mycobacterium abscessus. MSU-44147 exhibits additive or synergistic effects with antibiotics and can be used in research on multidrug-resistant isolates and infections of Mycobacterium abscessus[1].

体外研究
(In Vitro)

MSU-44147 (80 μM-0.08 nM；3 d) 可在体外强效抑制 Mycobacterium abscessus ATCC 19977 的生长，且在 5× MIC 浓度下呈现时间依赖性杀菌活性；同时，可强效抑制结核分枝杆菌菌株、脓肿分枝杆菌和耻垢分枝杆菌，在 80 μM 内对非分枝杆菌无活性，且对多重耐药脓肿分枝杆菌临床分离株表现出可变的抑菌活性[1]。
MSU-44147 (0.18 nM-160 μM; 3 d) 可破坏成熟的 Mycobacterium abscessus 生物膜，其 EC50 为 1.96 μM；同时可降低生物膜内的细菌活力，对应 EC50 为 0.18 μM[1]。
MSU-44147 (1-160 μM; 3 d) 在最高达 160 μM 的浓度下不会杀死处于非复制、营养饥饿状态的 Mycobacterium abscessus ATCC 19977[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MSU-44147 相关抗体:

Cell Viability Assay[1]

Cell Line: Mycobacterium tuberculosis strains, Mycobacterium abscessus, and Mycobacterium smegma
Concentration: 80 μM-0.08 nM
Incubation Time: 3 d
Result: Inhibited the growth of Mycobacterium abscessus ATCC 19977 by an EC50 of 0.46 μM and a MIC of 8.15 μM.
Effectively inhibited Mycobacterium tuberculosis strains (EC50 value of 0.19 to 0.26 μM), Mycobacterium abscessus (EC50 of 0.46 μM), and Mycobacterium smegma (EC50 of 4.16 μM).
分子量

313.36

Formula

C17H22F3NO
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MSU-44147 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

MSU-441473105177-29-2MSU44147MSU 44147Bacterialmycobacterium abscessus infectionMycobacterium abscessus ATCC 19977trehalose dimycolateMycobacterium smegmatismultidrug-resistant clinical Mycobacterium abscessus isolatesMmpL3murine bone marrow-derived macrophagesMycobacterium abscessusMycobacterium tuberculosisbiofilm formationInhibitorinhibitorinhibit

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