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  4. Neuro-DiO (chlorobenzenesulfonate)

Neuro-DiO chlorobenzenesulfonate 是一种带有绿色荧光的疏水性 C18 烷基链羰花青染料，常被用作血管标记剂、细胞内化剂及沉积剂。Neuro-DiO chlorobenzenesulfonate 可通过脂质体介导的灌注将烷基链插入内皮细胞质膜，从而实现对血管的标记。Neuro-DiO chlorobenzenesulfonate 也能够对癌细胞的细胞膜和细胞质进行染色，以辅助共聚焦显微镜的观察。Neuro-DiO chlorobenzenesulfonate 可从纳米海绵中释放并在小鼠视网膜表面聚集，进而内化到视网膜神经节细胞中，用于青光眼等相关研究。需注意，在小鼠体内进行脂质体介导的血管染色过程中，Neuro-DiO chlorobenzenesulfonate 可能会导致气道灌洗液发生渗漏。

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Neuro-DiO (chlorobenzenesulfonate)

Neuro-DiO (chlorobenzenesulfonate) Chemical Structure

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Neuro-DiO (chlorobenzenesulfonate) 相关抗体

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  • 生物活性

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生物活性

Neuro-DiO chlorobenzenesulfonate is a hydrophobic C18 alkyl chain carbocyanine dye with green fluorescence, commonly used as a vascular marker, cell internalizer and deposition agent. Neuro-DiO chlorobenzenesulfonate inserts its alkyl chain into the endothelial plasma membrane via liposome-mediated perfusion to achieve vascular labeling. Neuro-DiO chlorobenzenesulfonate can also stain the cell membrane and cytoplasm of cancer cells to assist in confocal microscopy observations. Neuro-DiO chlorobenzenesulfonate can be released from nanosponges and accumulate on the surface of mouse retina, then internalize into retinal ganglion cells, which is applicable to researches related to glaucoma and other diseases. It should be noted that during liposome-mediated vascular staining in mice, Neuro-DiO chlorobenzenesulfonate may cause leakage of airway lavage fluid[1][2][3].

体外研究
(In Vitro)

Neuro-DiO chlorobenzenesulfonate (5 μg/mL) 可有效染色 C6 大鼠脑胶质瘤细胞和 MCF-7 人乳腺癌腺癌细胞的细胞膜与细胞质，可用作脂质纳米颗粒定位共聚焦显微镜研究中的复染剂[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Neuro-DiO (chlorobenzenesulfonate) 相关抗体:
体内研究
(In Vivo)

Neuro-DiO chlorobenzenesulfonate (1 μL 载有 Neuro-DiO 的 50 nm 纳米海绵；玻璃体腔内注射；双眼) 可导致 Neuro-DiO 在视网膜中的沉积随时间增加 (注射后 28 天视网膜表面覆盖率最高可达 71.4%)，并被视网膜神经节细胞内化[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice[3]
Dosage: 1 μL of 50 nm nanosponges loaded with Neuro-DiO (10.6 weight % load, 0.58 mg/mL concentration)
Administration: Intravitreal injection; both eyes
Result: Reached 19.6% to 28.5% of retinal surface coverage at 3 days post-injection.
Reached 25.6% to 52.1% of retinal surface coverage at 7 to 14 days post-injection.
Reached 60.2% to 71.4% of retinal surface coverage at 28 days post-injection.
Colocalized with phosphorylated neurofilament-positive retinal ganglion cells at 1 week post-injection, with orthogonal projections confirming internalization within retinal ganglion cell somas.
分子量

1086.08

Formula

C67H105ClN2O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Neuro-DiO (chlorobenzenesulfonate) 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuro-DiO (chlorobenzenesulfonate)Fluorescent Dyelipid nanoparticle localizationcancer cell membranesC6 rat brain glioma cellsMCF-7 human breast adenocarcinoma cellsglaucomamouse retinal ganglion cellsmouse retinal surfacesendothelial cell plasma membranesInhibitorinhibitorinhibit

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