2. Cell Cycle/DNA Damage
  3. Deubiquitinase
  4. P6620

P6620 是一种具有口服活性的 USP7 抑制剂。P6620 可特异性结合 USP7，破坏其与 LRRC41 的相互作用。P6620 对肝细胞癌具有抗癌活性。P6620 可增强 Lenvatinib (HY-10981) 在异种移植小鼠模型中的抗肿瘤效果。P6620 可用于肝细胞癌的研究。

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P6620

P6620 Chemical Structure

CAS No. : 2009272-81-3

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P6620 相关抗体

Top Publications Citing Use of Products

查看 Deubiquitinase 亚型特异性产品:

查看所有亚型
USP1 USP2 USP4 USP7 USP8 USP10 USP21 USP30 UCHL1 USP11 USP15

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

P6620 is an orally active USP7 inhibitor. P6620 specifically binds to USP7 and disrupts its interaction with LRRC41. P6620 exhibits anticancer activity against hepatocellular carcinoma. P6620 enhances the antitumor effect of Lenvatinib (HY-10981) in xenograft mouse models. P6620 can be used for the research of hepatocellular carcinoma[1].

IC50 & Target[1]

USP7

 

体外研究
(In Vitro)

P6620 (0-2.0 μM; 24-72 h) 可强效抑制肝癌细胞 MHCC97H 和 HepG2 的活力，其 IC50 为 11.31 μM[1]。
P6620 (5-20 μM; 48 h) 以剂量依赖的方式降低 MHCC97H 和 HepG2 肝癌细胞中 USP7 和 LRRC41 的蛋白水平[1]。
P6620 (10-20 μM; 48 h) 可显著抑制 MHCC97H 和 HepG2 肝癌细胞的侵袭与迁移能力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

P6620 相关抗体:

Cell Viability Assay[1]

Cell Line: human hepatocellular carcinoma MHCC97H, HepG2 cells
Concentration: 0-2.0 μM (viability measurement); 10, 20 μM (24-72 h incubation)
Incubation Time: 24-72 h (10, 20 μM treatment)
Result: Reduced HCC cell viability in a concentration-dependent manner, with an IC50 of 11.31 μM.
Significantly decreased the viability of MHCC97H and HepG2 cells compared with untreated controls when treated with 10 μM or 20 μM.

Western Blot Analysis[1]

Cell Line: human hepatocellular carcinoma MHCC97H, HepG2 cells
Concentration: 5-20 μM (48 h incubation); 10 μM (48 h incubation, followed by 8 h incubation with 10 μM MG132)
Incubation Time: 48 h (5-20 μM treatment); 48 h + 8 h (10 μM P6620 + 10 μM MG132 treatment)
Result: Dose-dependently reduced USP7 and LRRC41 protein levels in MHCC97H and HepG2 cells when treated with 5, 10, or 20 μM for 48 h.
体内研究
(In Vivo)

P6620 (20 mg/kg；口服；每周 5 次；持续 14 天) 可显著降低肝细胞癌异种移植小鼠模型的肿瘤重量，与 Lenvatinib (HY-10981) 联合使用时效果增强[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: nude mice (male, 4 weeks old, subcutaneously inoculated with MHCC97H cells)[1]
Dosage: 20 mg/kg
Administration: p.o.; 5 times weekly; 14 days
Result: Significantly reduced tumour weight compared with the control group.
Significantly reduced Ki67 and USP7 expression in tumour tissues relative to controls.
分子量

306.36

Formula

C19H18N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

P6620 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P66202009272-81-3P 6620P-6620DeubiquitinaseDUBsxenograft mouse modelsLRRC41lenvatinibhepatocellular carcinomaHepG2MG132ubiquitin-dependent degradationUSP7MHCC97HKi67Inhibitorinhibitorinhibit

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目录号：
HY-183078
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