2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. PD-1/PD-L1-IN-60

PD-1/PD-L1-IN-60 是小分子免疫探针 [18F] LG‑8 的对应物，两者一起可实现免疫诊疗一体化。PD-1/PD-L1-IN-60 在 PD‑L1 摄取量高的黑色素瘤、肺癌小鼠模型中展现出强效抗肿瘤活性。PD-1/PD-L1-IN-60 可用于黑色素瘤、肺癌的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

PD-1/PD-L1-IN-60

PD-1/PD-L1-IN-60 Chemical Structure

CAS No. : 3095344-37-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

PD-1/PD-L1-IN-60 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PD-1/PD-L1-IN-60 is the counterpart of the small-molecule immuno-probe [18F] LG‑8, and the two together enable integrated immuno-diagnosis and therapy. PD-1/PD-L1-IN-60 exhibits potent anti-tumor activity in mouse models of melanoma and lung cancer with high PD‑L1 uptake. PD-1/PD-L1-IN-60 can be used for relevant research on melanoma and lung cancer[1].

体内研究
(In Vivo)

PD-1/PD-L1-IN-60 (LG-8)(2 mg/kg；腹腔注射；每隔 1 天给药；共 7 次) 在 B16−F10 黑色素瘤模型中展现出强效抗肿瘤活性[1]。
PD-1/PD-L1-IN-60 (2 mg/kg；腹腔注射；每隔 1 天给药 1 次；共给药 4 次) 在 Cisplatin (HY-17394) 诱导的 PD-L1 高表达 LLC 肺癌模型中表现出显著的抗肿瘤功效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (female)[1]
Dosage: 2 mg/kg
Administration: i.p.; every other day; 7 total doses
Result: Reduced mean tumor volume to 110 mm3 .
Markedly diminished PD-L1 expression in tumors.
Significantly enhanced CD8+ T-cell infiltration relative to control.
Caused a slight increase in body weight with no significant difference from controls.
Animal Model: C57BL/6 (female)[1]
Dosage: 2 mg/kg
Administration: i.p.; every other day; 4 total doses
Result: Reduced mean tumor volume to 1129 mm3 in PD-L1 high-expression subgroup.
Caused no significant weight loss in treated mice.
分子量

1057.59

Formula

C53H70ClFN4O15
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PD-1/PD-L1-IN-60 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-1/PD-L1-IN-603095344-37-6PD-1/PD-L1PD-1/Programmed death-ligand 1PD-L1 inhibitormelanomalung cancerC57BL/6 mice
Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
PD-1/PD-L1-IN-60
目录号：
HY-181816
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z