2. Immunology/Inflammation
  3. Aryl Hydrocarbon Receptor
  4. Penisimplicissin

Penisimplicissin 是一种 Funicone 样化合物、抗病毒剂。Penisimplicissin 降低 AhR、病毒核衣壳蛋白表达。Penisimplicissin 可改善 CCoV 感染细胞的细胞活力与形态学特征。Penisimplicissin 可抑制 CCoV 感染。Penisimplicissin 可用于犬冠状病毒感染的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Penisimplicissin

Penisimplicissin Chemical Structure

CAS No. : 873207-55-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Penisimplicissin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Penisimplicissin is a funicone-like compound and antiviral agent. Penisimplicissin reduces the expression of AhR and viral nucleocapsid protein. Penisimplicissin improves the cell viability and morphological characteristics of CCoV-infected cells. Penisimplicissin inhibits CCoV infection. Penisimplicissin can be used in studies related to canine coronavirus infection[1].

体外研究
(In Vitro)

Penisimplicissin (0.1-10 μM; 48 h) 在犬纤维肉瘤 A72 细胞中的 IC50 为 4.9562 μM[1]。
Penisimplicissin (0.1-2.5 μM; 48 h) 在 0.5 μM 和 2.5 μM 浓度下可显著提高感染犬冠状病毒 (CCoV) 的犬纤维肉瘤 A72 细胞经 48 小时处理后的细胞活力[1]。
Penisimplicissin (0.5 μM) 可降低感染犬冠状病毒 (CCoV) 的犬纤维肉瘤 A72 细胞死亡的形态学特征，包括细胞皱缩、固缩和细胞脱落[1]。
Penisimplicissin (0.5 μM; 48 h post-infection) 可在处理 48 h 后显著降低感染 CCoV 的犬纤维肉瘤 A72 细胞的病毒产量和细胞病变效应[1]。
Penisimplicissin (0.5 μM; 24 h) 可显著降低未感染和感染 CCoV 的犬纤维肉瘤 A72 细胞中芳香烃受体的表达，病毒核衣壳蛋白表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Penisimplicissin 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: canine fibrosarcoma A72 cells
Concentration: 0.1 μM, 0.5 μM, 1 μM, 2.5 μM, 5 μM, 10 μM
Incubation Time: 48 h
Result: Showed no significant difference in cell viability compared to vehicle control at 0.1, 0.5, and 2.5 μM (p > 0.05).
Significantly reduced cell viability at 1 μM (p < 0.05), 5 μM (p < 0.01), and 10 μM (p < 0.001).
Determined an IC50 of 4.9562 μM in A72 cells.

Cell Viability Assay[1]

Cell Line: canine fibrosarcoma A72 cells infected with canine coronavirus (CCoV)
Concentration: 0.1 μM, 0.5 μM, 2.5 μM
Incubation Time: 48 h post-infection
Result: Showed no significant change in cell viability compared to untreated infected cells at 0.1 μM (p > 0.05).
Significantly increased cell viability in CCoV-infected A72 cells at 0.5 μM (p < 0.01) and 2.5 μM (p < 0.05).
Led to selection of the 0.5 μM dose for subsequent experiments.

Real Time qPCR[1]

Cell Line: canine fibrosarcoma A72 cells infected with CCoV
Concentration: 0.5 μM
Incubation Time: 48 h post-infection
Result: Caused a significant (p < 0.05) decrease in CCoV titer, measured as Log TCID50/mL, compared to untreated infected cells.
Resulted in a decreased cytopathic effect in treated cells relative to untreated infected cells.

Immunofluorescence[1]

Cell Line: canine fibrosarcoma A72 cells (uninfected and CCoV-infected)
Concentration: 0.5 μM
Incubation Time: 24 h post-treatment (uninfected cells); 24 h post-infection (infected cells)
Result: Caused a significant (p < 0.001) reduction in AhR expression in uninfected A72 cells compared to vehicle control.
Resulted in significant reductions in both AhR (p < 0.001) and viral NP (p < 0.001) expression in CCoV-infected A72 cells compared to untreated infected cells.
分子量

302.28

Formula

C16H14O6
CAS 号
结构分类
初始来源

Talaromyces pinophilus
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Penisimplicissin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Penisimplicissin873207-55-7Aryl Hydrocarbon ReceptorAhRlysosomeviral nucleocapsid proteinligand-activated transcription factorscanine coronavirusaryl hydrocarbon receptorlysosomal alkalinizationcanine fibrosarcoma A72 cellscell viabilitycytopathic effectcytoprotective agentInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Penisimplicissin
目录号：
HY-182495
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z