2. R-MDMA

R-MDMA，一种 4-亚甲二氧基甲基苯丙胺 (MDMA) 异构体，是一种 5-HT2A/5-HT2C 受体拮抗剂，其 IC50 值分别为 629 nM 和 61.4 nM。R-MDMA 可促进皮质神经元生长。R-MDMA 可促进恐惧消退学习，并在临床前啮齿动物模型中产生类抗抑郁作用。R-MDMA 可用于创伤后应激障碍和抑郁症的相关研究。

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R-MDMA

R-MDMA Chemical Structure

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Other Forms of R-MDMA:

R-MDMA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

R-MDMA, 4-methylenedioxymethamphetamine (MDMA) isomer, is a 5-HT2A/5-HT2C receptor antagonist with an IC50 of 629 and 61.4 nM. R-MDMA promotes cortical neuron growth. R-MDMA facilitates fear extinction learning and produces antidepressant-like effects in preclinical rodent models. R-MDMA can be used for the researches of post-traumatic stress disorder and depression[1].

体外研究
(In Vitro)

R-MDMA (10 pM-10 μM; 24-72 h) 可促进皮层神经元生长[1]。
R-MDMA (100 μM; 15 min) 可诱导表达 SERT 的 HEK293T 细胞释放血清素[1]。
R-MDMA (10 pM-100 μM; 5 min) 在 HEK293T 细胞中作为 5-HT2A 受体的中等效力拮抗剂，其 IC50 为 629 nM[1]。
R-MDMA (10 pM-100 μM; 5 min) 可作为 HEK293T 细胞中 5-HT2C 受体的中等效力拮抗剂，其 IC50 为 61.4 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

R-MDMA 相关抗体:

Cell Proliferation Assay[1]

Cell Line: cortical neurons
Concentration: 10 pM, 1, 100 nM, 10 μM
Incubation Time: 24, 72 h
Result: Promoted cortical neuron growth.
体内研究
(In Vivo)

R-MDMA (12.5-50 mg/kg；腹腔注射；单次给药) 在 12.5 mg/kg 剂量下会降低自主活动能力，在 50 mg/kg 剂量下会增强自主活动能力，在所有测试剂量下均会增强趋触性，在 25 mg/kg 和 50 mg/kg 剂量下会导致短暂的体温下降，且在任何测试剂量下均不会诱发甩头反应[1]。
R-MDMA (12.5-25 mg/kg；腹腔注射；单次给药；消退训练前 30 min) 可促进恐惧消退学习，在小鼠恐惧条件化模型中使僵住行为持续减少[1]。
R-MDMA (12.5-25 mg/kg；腹腔注射；单次给药) 在 25 mg/kg 剂量下可在小鼠悬尾实验中产生持续的类抗抑郁作用[1]。
R-MDMA (20 mg/kg；腹腔注射；单次给药；于社交互动训练期间给药) 不会在小鼠中产生具有统计学意义的社交条件位置偏好[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (9-13 weeks old, mixed male and female)[1]
Dosage: 12.5 mg/kg; 25 mg/kg; 50 mg/kg
Administration: i.p.; single dose
Result: Decreased locomotion at 12.5 mg/kg.
Increased locomotion at 50 mg/kg.
Caused significantly less time spent in the arena center (increased thigmotaxis) at all doses.
Did not induce head-twitch response at any dose.
Caused transient decrease in body temperature at 30 min post-administration of 25 mg/kg and 50 mg/kg, which resolved by 60 min.
Produced no body temperature changes at 12.5 mg/kg.
Animal Model: Depressant C57BL/6J (9-13 weeks old, mixed male and female)[1]
Dosage: 12.5 mg/kg; 25 mg/kg
Administration: i.p.; single dose
Result: Reduced immobility time to a comparable extent to positive control Ketamine (3 mg/kg) at 25 mg/kg.
Did not produce statistically significant antidepressant-like response at 12.5 mg/kg.
Had its antidepressant-like effect blocked when pretreated with 5-HT2 antagonist Ketanserin (HY-10562) (4 mg/kg, i.p., 10 min prior) at 25 mg/kg.
分子量

192.25

Formula

C12H16O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

R-MDMA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

R-MDMApost-traumatic stress disorderdepressionmouse tail suspension test5-HT2A receptorSERT-expressing HEK293T cells5-HT2C receptormouse fear conditioning modelcortical neuronspreclinical rodent modelsGq signaling pathwaysInhibitorinhibitorinhibit

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