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20-lyase

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By Targets:	Cytochrome P450 (9) Reference Standards (2)
By Research Areas:	Cancer (7) Endocrinology (1)

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Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-70013

Abiraterone 20 篇以上引用文献 CB-7598	Cytochrome P450	Cancer
阿比特龙 Abiraterone 是一种有效的不可逆的 CYP17A1 抑制剂，具有抗雄激素活性，抑制细胞色素 p450 酶 CYP17 的 17α-羟化酶和 17,20-裂合酶活性，IC₅₀ 值分别为 2.5 nM 和 15 nM.

HY-70013S

Abiraterone-d4 CB-7598-d₄	Cytochrome P450	Cancer
阿比特龙 d₄ Abiraterone-d₄ 是 Abiraterone 的氘代物。Abiraterone 是一种有效的不可逆的 CYP17A1 抑制剂，具有抗雄激素活性，抑制细胞色素 p450 酶 CYP17 的 17α-羟化酶和 17,20-裂合酶活性，IC₅₀ 值分别为 2.5 nM 和 15 nM.

HY-10505

Orteronel 2 篇文献验证 TAK-700	Cytochrome P450	Cancer
Orteronel (TAK-700) 是一种高度选择性的人17，20-裂解酶 (*17,20-lyase, CYP17) 抑制剂，IC₅₀* 值为 38 nM，对其选择性是对 11-hydroxylase 和 CYP3A4 的 1000 多倍。

HY-148430

4-Pyridylmethyl adamantanecarboxamide	Cytochrome P450	Cancer
4-Pyridylmethyl adamantanecarboxamide (Compound 11) 是一种 Aromatase 抑制剂，其对 hAromatase 的 IC₅₀ 为 1.5 μM。4-Pyridylmethyl adamantanecarboxamide 可抑制睾丸细胞色素 P450_17α 的 C17,20-裂解酶活性，其 IC₅₀ 为 1600 nM；同时可抑制该酶的 17α-羟化酶活性，IC₅₀ 为 7700 nM。4-Pyridylmethyl adamantanecarboxamide 可用于前列腺癌的研究。

HY-120067

YM116	Cytochrome P450	Endocrinology
YM116 是一种口服有效的竞争性 CYP17A1 (17,20-裂解酶) 抑制剂 (Ki: 0.38 nM)。YM116 通过优先抑制 C17-20 裂解酶活性来减少肾上腺雄激素的合成。YM116 可降低血清睾酮浓度，降低硫酸脱氢表雄酮水平，并减轻前列腺重量。

HY-156481

SU-8000	Cytochrome P450	Others
SU-8000 是一种选择性大鼠睾丸 17α-羟化酶和 C_17-20-裂解酶的抑制剂。SU-8000 给药怀孕大鼠后，会导致雄性胎儿出现尿道下裂。

HY-70013R

Abiraterone (Standard) CB-7598 (Standard)	Reference Standards Cytochrome P450	Cancer
阿比特龙 (标准品) Abiraterone (Standard)是 Abiraterone 的分析标准品。本产品用于研究及分析应用。Abiraterone 是一种有效的不可逆的 CYP17A1 抑制剂，具有抗雄激素活性，抑制细胞色素 p450 酶 CYP17 的 17α-羟化酶和 17,20-裂合酶活性，IC₅₀ 值分别为 2.5 nM 和 15 nM.

HY-10505R

Orteronel (Standard)	Reference Standards Cytochrome P450	Cancer
Orteronel (Standard) 是 Orteronel (HY-10505) 的分析标准品。本产品用于研究及分析应用。Orteronel (TAK-700) 是一种高度选择性的人17，20-裂解酶 (*17,20-lyase, CYP17) 抑制剂，IC₅₀* 值为 38 nM，对其选择性是对 11-hydroxylase 和 CYP3A4 的 1000 多倍。

HY-136745

Aromatase-IN-1	Cytochrome P450	Cancer
Aromatase-IN-1 是一种竞争性芳香化酶 (P450arom) 抑制剂，对人源靶点的 IC₅₀ 为 40 nM，K_i 为 1.05 nM。Aromatase-IN-1 通过咪唑氮原子与芳香化酶的血红素铁配位结合。Aromatase-IN-1 可用于乳腺癌的相关研究。

Cat. No.	Product Name	Chemical Structure

HY-70013S

Abiraterone-d4
Abiraterone-d₄ 是 Abiraterone 的氘代物。Abiraterone 是一种有效的不可逆的 CYP17A1 抑制剂，具有抗雄激素活性，抑制细胞色素 p450 酶 CYP17 的 17α-羟化酶和 17,20-裂合酶活性，IC₅₀ 值分别为 2.5 nM 和 15 nM.

Cat. No.	Compare	Product Name	Application	Reactivity	图片

HY-P85566

	Cytochrome P450 17A1 Antibody (YA5258) 20 lyase; CP17A_HUMAN; CPT7; CYP17; CYP17A1; CYPXVII; Cytochrome P450 17A1; Cytochrome P450 family 17; Cytochrome P450 family 17 subfamily A polypeptide 1; Cytochrome p450 subfamily XVII; steroid 17 alpha hydroxylase; adrenal hyperplasia; Cytochrome p450 XVIIA1; Cytochrome P450-C17; Cytochrome P450c17; OTTHUMP00000020382; P450 C17; P450c17; S17AH; Steroid 17 alpha hydroxylase/17,20 lyase; Steroid 17 alpha monooxygenase; Steroid 17-alpha-hydroxylase/17; Steroid 17-alpha-monooxygenase.	WB	Human
	Cytochrome P450 17A1 Antibody (YA5258) 是一个小鼠来源、无偶联标记、抗 Cytochrome P450 17A1 的单克隆抗体。

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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