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3β-hydroxysteroid dehydrogenase

" in MCE Product Catalog:

By Targets:	3β-HSD (3) Androgen Receptor (1) Apoptosis (1) Bacterial (1) CDK (1) Endogenous Metabolite (4) Fungal (1) Isotope-Labeled Compounds (2) Reference Standards (1)
By Research Areas:	Cancer (3) Endocrinology (2) Infection (1) Metabolic Disease (4)

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Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-113263

17a-Hydroxypregnenolone 2 篇文献验证 17-OHP5	Endogenous Metabolite	Metabolic Disease
17a-Hydroxypregnenolone (17-OHP5) 是 Pregnenolone (HY-B0151) 的一种代谢产物，也是 Dehydroepiandrosterone (HY-14650) 生物合成过程中的前体物质。17a-Hydroxypregnenolone 是 3β-羟类固醇脱氢酶 (3β-HSD) 的底物。

HY-105128

Epostane WIN 32729	3β-HSD	Endocrinology
Epostane (WIN 32729) 是口服有效的 3β-hydroxysteroid dehydrogenase 抑制剂，IC₅₀ 为 1.45 nM。Epostane 抑制大鼠排卵和妊娠。

HY-175592

HEAL-116	3β-HSD	Cancer
HEAL-116 是一种强效、特异性且具有口服活性的 1 型 3β-羟类固醇脱氢酶 (3βHSD1) 抑制剂，其 IC₅₀ 值为 1.18 μM，K_D 值为 1.32 μM。HEAL-116 可抑制 DHEA (HY-14650) 的代谢以及 DHEA 诱导的靶基因表达和细胞增殖。HEAL-116 可用于癌症研究，如前列腺癌。

HY-113263R

17a-Hydroxypregnenolone (Standard) 2 篇文献验证 17-OHP5 (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
17a-Hydroxypregnenolone (Standard) 是 17a-Hydroxypregnenolone 的分析标准品。本产品用于研究及分析应用。17a-Hydroxypregnenolone 是 Pregnenolone (HY-B0151) 的一种代谢产物，也是 Dehydroepiandrosterone (HY-14650) 生物合成过程中的前体物质。17a-Hydroxypregnenolone 是 3β-羟类固醇脱氢酶 (3β-HSD) 的底物。

HY-113263S

17a-Hydroxypregnenolone-d3 17-OHP5-d₃	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
17a-Hydroxypregnenolone-d₃ (17-OHP5-d₃) 是 17a-Hydroxypregnenolone (HY-113263) 的氘代物。17a-Hydroxypregnenolone 是 Pregnenolone (HY-B0151) 的一种代谢产物，也是 Dehydroepiandrosterone (HY-14650) 生物合成过程中的前体物质。17a-Hydroxypregnenolone 是 3β-羟类固醇脱氢酶 (3β-HSD) 的底物。

HY-174244

3βHSD1-IN-1	3β-HSD Androgen Receptor	Cancer
3βHSD1-IN-1 (Compound 46) 是一种 3β-羟类固醇脱氢酶 1 (3βHSD1) 抑制剂，IC₅₀ 为 55 nM。3βHSD1-IN-1 能有效抑制雄激素受体活性。3βHSD1-IN-1 可用于前列腺癌等疾病的研究。

HY-113263S1

17α-Hydroxypregnenolone-13C2,d2 17-OHP5-¹³C₂,d₂	Endogenous Metabolite Isotope-Labeled Compounds	Metabolic Disease
17α-Hydroxypregnenolone-¹³C₂,d₂ 是 ¹³C 标记的 17α-Hydroxypregnenolone 的氘代物。17a-Hydroxypregnenolone 是 Pregnenolone (HY-B0151) 的一种代谢产物，也是 Dehydroepiandrosterone (HY-14650) 生物合成过程中的前体物质。17a-Hydroxypregnenolone 是 3β-羟类固醇脱氢酶 (3β-HSD) 的底物。

HY-W714186

Etaconazol Etaconazole	Bacterial Fungal	Infection
乙环唑 Etaconazol (Etaconazole) 是一种唑类杀菌剂。Etaconazol 具有内分泌干扰潜力，通过抑制 3β- 羟基类固醇脱氢酶 (3β-HSD1) 抑制胎盘类固醇生成。Etaconazol 可结合靶酶的 NAD⁺/类固醇结合位点，作用于游离酶和酶-底物复合物以抑制其活性。

HY-182447

Contragestazol DL111-IT	CDK Apoptosis	Endocrinology Cancer
Contragestazol (DL111-IT) 是一种非激素类抗生育剂。Contragestazol 可降低 Cyclin D1 和 CDK4 的表达，增加总视网膜母细胞瘤蛋白 (pRb) 的表达，并降低过度磷酸化的 pRb 水平。Contragestazol 可诱导 G₀/G₁ 期细胞周期阻滞。Contragestazol 通过诱导黄体细胞凋亡 (Apoptosis) 及降低子宫内多胺水平，从而抑制胚胎发育。Contragestazol 对前列腺癌、 S180 肿瘤和 H22 肿瘤具有抗肿瘤活性。Contragestazol 在动物体内表现出极强的终止早期妊娠活性。

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113263

17a-Hydroxypregnenolone 2 篇文献验证 17-OHP5	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Classification of Application Fields Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Endogenous Metabolite
17a-Hydroxypregnenolone (17-OHP5) 是 Pregnenolone (HY-B0151) 的一种代谢产物，也是 Dehydroepiandrosterone (HY-14650) 生物合成过程中的前体物质。17a-Hydroxypregnenolone 是 3β-羟类固醇脱氢酶 (3β-HSD) 的底物。

Cat. No.	Product Name	Chemical Structure

HY-113263S

17a-Hydroxypregnenolone-d3
17a-Hydroxypregnenolone-d₃ (17-OHP5-d₃) 是 17a-Hydroxypregnenolone (HY-113263) 的氘代物。17a-Hydroxypregnenolone 是 Pregnenolone (HY-B0151) 的一种代谢产物，也是 Dehydroepiandrosterone (HY-14650) 生物合成过程中的前体物质。17a-Hydroxypregnenolone 是 3β-羟类固醇脱氢酶 (3β-HSD) 的底物。

HY-113263S1

17α-Hydroxypregnenolone-13C2,d2
17α-Hydroxypregnenolone-¹³C₂,d₂ 是 ¹³C 标记的 17α-Hydroxypregnenolone 的氘代物。17a-Hydroxypregnenolone 是 Pregnenolone (HY-B0151) 的一种代谢产物，也是 Dehydroepiandrosterone (HY-14650) 生物合成过程中的前体物质。17a-Hydroxypregnenolone 是 3β-羟类固醇脱氢酶 (3β-HSD) 的底物。

Cat. No.	Compare	Product Name	Application	Reactivity	图片

HY-P81196

	HSD3B1 Antibody (YA3519) 1 篇文献验证 3BHS1_HUMAN; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; 3-beta-hydroxy-5-ene steroid dehydrogenase 1; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase 1; EC:1.1.1.145; 3-beta-hydroxysteroid 3-dehydrogenase 1; EC:1.1.1.270; Delta-5-3-ketosteroid isomerase; Dihydrotestosterone oxidoreductase. EC:1.1.1.210; Steroid Delta-isomerase 1; EC:5.3.3.1; Trophoblast antigen FDO161G; 3BH; HSDB3A;	WB, ICC/IF	Human
	HSD3B1 Antibody (YA3519) 是一个兔来源、无偶联标记、抗 HSD3B1 的 IgG 单克隆抗体。

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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3β-hydroxysteroid dehydrogenase

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