2. Cell Cycle/DNA Damage Epigenetics Apoptosis PI3K/Akt/mTOR
  3. HDAC Caspase Akt
  4. HDAC1-IN-14

HDAC1-IN-14 是一种基于吲哚的苯甲酰胺类选择性 HDAC1 抑制剂，IC50 为 77 nM。HDAC1-IN-14 可作为抗增殖剂，在多种癌细胞中的 GI50 值处于纳摩尔至低微摩尔水平。HDAC1-IN-14 可在结肠癌细胞中诱导 G0-G1 期细胞周期阻滞。HDAC1-IN-14 上调 Caspase-3、Cyto-C 和 Bax 的表达，下调 AKT-1 的表达。HDAC1-IN-14 可用于白血病、非小细胞肺癌、结肠癌、中枢神经系统癌、黑色素瘤、卵巢癌、肾癌、前列腺癌、乳腺癌的相关研究。

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HDAC1-IN-14

HDAC1-IN-14 Chemical Structure

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HDAC1-IN-14 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC1-IN-14 is an indole-based benzamide selective HDAC1 inhibitor with an IC50 of 77 nM. HDAC1-IN-14 acts as an antiproliferative agent, with GI50 values ranging from nanomolar to low micromolar levels in various cancer cells. HDAC1-IN-14 induces G0-G1 cell cycle arrest in colon cancer cells. HDAC1-IN-14 upregulates the expression of Caspase-3, Cyto-C and Bax, and downregulates the expression of AKT-1. HDAC1-IN-14 can be used in research related to leukemia, non-small cell lung cancer, colon cancer, central nervous system cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer[1].

IC50 & Target[1]

HDAC1

77 nM ()

体外研究
(In Vitro)

HDAC1-IN-14 (Compound 23c) (10 μM) 可强效抑制涵盖多种癌症类型的 NCI-60 肿瘤细胞系的生长，其平均 GI50 为 1 μM，对白血病细胞系的活性最强[1]。
HDAC1-IN-14 可抑制 HCT-116 结肠癌细胞的增殖，其 IC50 为 3 μM[1]。
HDAC1-IN-14 (3 μM; 24 h) 可在 HCT-116 结肠癌细胞中诱导 G0-G1 期细胞周期阻滞，处于 G0-G1 期的细胞占比为 89.42%[1]。
HDAC1-IN-14 (3 μM; 24 h) 可调控 HCT-116 结肠癌细胞中关键凋亡通路基因的表达，包括上调促凋亡蛋白 Caspase-3、Cyto-C 和 Bax 的表达，以及下调 AKT-1 的表达[1]。
HDAC1-IN-14 (3 μM; 24 h) 可使 HCT-116 结肠癌细胞中的总细胞 HDAC 活性抑制 5%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC1-IN-14 相关抗体:

Cell Cycle Analysis[1]

Cell Line: HCT-116 colon cancer cells
Concentration: 3 μM
Incubation Time: 24 h
Result: Induced G0-G1 phase cell cycle arrest, with 89.42% of cells in the G0-G1 phase, 3.86% in the S phase, 0.01% in the G2-M phase, and 2.35% in the Sub G0-G1 phase.

Real Time qPCR[1]

Cell Line: HCT-116 colon cancer cells
Concentration: 3 μM
Incubation Time: 24 h
Result: Induced overexpression of Caspase-3 (3-fold), Cyto-C (3-fold), and Bax (16-fold).
Downregulated AKT-1 (0.6-fold).
Showed no significant effect on Bcl-2 expression (2-fold).
Resulted in a Bax/Bcl-2 ratio of 8.
分子量

490.55

Formula

C30H26N4O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC1-IN-14 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC1-IN-14HDACCaspaseAktHistone deacetylasesPKBProtein kinase Bmelanomacns cancerrenal cancerHDAC1non-small cell lung cancercolon cancerHDAC6ovarian cancerclass I HDAC isoformsleukemiaInhibitorinhibitorinhibit

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