2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Octanoylcarnitine

Octanoylcarnitine 是一种口服有效的脂肪酸 β-氧化中的中链酰基肉碱转运中间体。Octanoylcarnitine 可被肉碱乙酰基转移酶 (CrAT) 转化为辛酰辅酶 A，进而通过心脏和骨骼肌线粒体中的 β-氧化产生能量。Octanoylcarnitine 可增强握力和跑步机耐力，减轻乳酸性酸中毒，分布于肌肉和心脏组织，提高游离肉碱水平，并缓解线粒体应激。Octanoylcarnitine 与长链脂肪酸代谢相关，在转移性胰腺导管腺癌患者中与皮下脂肪面积呈正相关，且与视网膜中央动脉阻塞 (CRAO) 密切相关。

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Octanoylcarnitine

Octanoylcarnitine Chemical Structure

CAS No. : 3671-77-0

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Octanoylcarnitine 的其他形式现货产品:

Other Forms of Octanoylcarnitine:

Octanoylcarnitine 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Octanoylcarnitine is an orally active medium-chain acylcarnitine transport intermediate in fatty acid β-oxidation. Octanoylcarnitine is converted to octanoyl-CoA by carnitine acetyltransferase (CrAT), which then generates energy via β-oxidation in mitochondria of the heart and skeletal muscle. Octanoylcarnitine enhances grip strength and treadmill endurance, alleviates lactic acidosis, distributes in muscle and heart tissues, increases free carnitine levels, and mitigates mitochondrial stress. Octanoylcarnitine is associated with long-chain fatty acid metabolism, shows a positive correlation with subcutaneous fat area in patients with metastatic pancreatic ductal adenocarcinoma, and is closely related to central retinal artery occlusion (CRAO)[1][2][3].

体外研究
(In Vitro)

Octanoylcarnitine (50 μM) 可在分离的野生型小鼠骨骼肌线粒体中维持旺盛的呼吸作用以产生能量[1]。
Octanoylcarnitine (25 μM; 1 min) 可在体外被重组人源 CrAT 和 CPT2 转化为辛酰辅酶 A，表现出酶活性[1]。
Octanoylcarnitine (50 μM; 1 h) 在 37℃孵育后可被野生型小鼠骨骼肌和心脏匀浆高效转化为辛酰基辅酶 A[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Octanoylcarnitine 相关抗体:
体内研究
(In Vivo)

Octanoylcarnitine (0.5 mg/g 或 3% w/w；单次灌胃或自由摄取 10 天) 可提升 LCAD-KO 小鼠的运动能力、减轻其运动后乳酸性酸中毒，还能升高组织和血清中短链酰基肉碱水平[1]。
Octanoylcarnitine (0.5 mg/g；灌胃；单次给药) 可显著改善肌肉特异性 CPT2 缺陷小鼠的跑步机运动能力与握力[1]。
Octanoylcarnitine (0.5 mg/g；灌胃；单次给药) 在健康小鼠体内可快速代谢为 CO2，代谢产物在 10 分钟内即可被检测到随呼气排出[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Long-Chain Acyl-CoA Dehydrogenase Knockout (LCAD-KO) (male, 12-16 weeks, LC-FAOD model)[1]
Dosage: 0.5 mg/g (exercise testing); 3% w/w (chronic feeding)
Administration: i.g.; single dose, 20 minutes prior to exercise testing; i.g.; mixed into powdered diet, ad libitum for 10 days
Result: Significantly increased treadmill running distance compared to vehicle control.
Significantly reduced post-run blood lactate levels compared to vehicle control.
Did not alter serum levels of diagnostic long-chain acylcarnitine C14:1-carnitine.
Increased serum levels of downstream short-chain acylcarnitines (C8, C6, C4, C2, free carnitine) to normal or above-normal levels.
Significantly increased free carnitine levels in liver, heart, and muscle.
Significantly increased octanoylcarnitine levels in liver and muscle.
Animal Model: muscle-specific Carnitine Palmitoyltransferase 2 Knockout (CPT2ᵐᴷᴼ) (male, LC-FAOD model)[1]
Dosage: 0.5 mg/g
Administration: i.g.; single dose, 20 minutes prior to functional testing
Result: Significantly increased treadmill top speed compared to vehicle control.
Significantly increased grip strength compared to vehicle control.
分子量

287.40

Formula

C15H29NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Octanoylcarnitine 相关分类

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Keywords:

Octanoylcarnitine3671-77-0Endogenous Metabolitecentral retinal artery occlusionLCAD-KO micemuscle-specific CPT2-deficient micecarnitine acetyltransferaseβ-oxidationmetastatic pancreatic ductal adenocarcinomaCrATlong-chain fatty acid oxidation disordersskeletal muscle mitochondriaheart mitochondriaInhibitorinhibitorinhibit

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