寡霉素 B
Oligomycin B 是一种抗生素 (antibiotic)，可作为 ATP 合酶 (ATP Synthase) 的非选择性抑制剂。Oligomycin B 可升高线粒体膜电位。Oligomycin B 诱导细胞凋亡 (apoptosis) 和坏死。Oligomycin B 会削弱葡萄霜霉菌游动孢子的运动能力并诱导其裂解。Oligomycin B 抑制小麦稻瘟病菌，并抑制小麦瘟病的发生。Oligomycin B 可降低灰葡萄孢菌的菌丝生长与孢子萌发水平，保护拟南芥抵御灰葡萄孢菌的侵害。Oligomycin B 会加重大脑皮质挫伤大鼠的脑细胞毒性水肿，升高颅内压与脑含水量，并加剧其线粒体损伤。Oligomycin B 可用于葡萄霜霉病、创伤性脑损伤、小麦瘟病、灰霉病的相关研究。
银杏内酯 B
Ginkgolide B (BN-52021) 是一种萜内酯，一种有效的血小板活化因子拮抗剂。Ginkgolide B 通过激活 PXR 保护内皮细胞免受外源性和内生性物质引起的损伤。Ginkgolide B 可透过脑血屏障。Ginkgolide B 具有抗氧化、抗炎、抗肿瘤和抗凋亡活性。Ginkgolide B 对缺血引起的损伤具有显着的神经保护作用。
刺五加皂苷 B
Ciwujianoside B 是一种具有口服活性且可穿透血脑屏障的辐射防护剂和记忆增强剂。Ciwujianoside B 减少辐射诱导的 DNA 损伤、细胞周期阻滞和凋亡 (apoptosis)、下调 NF-κB 和 Bax/Bcl-2 比值，增强骨髓细胞增殖能力。Ciwujianoside B 可增强正常小鼠的物体识别记忆，并诱导原代培养皮质神经元的树突延伸。Ciwujianoside B 可用于造血系统辐射损伤和记忆增强相关研究。
银杏内酯 B (标准品)
Ginkgolide B (Standard)是 Ginkgolide B 的分析标准品。本产品用于研究及分析应用。Ginkgolide B (BN-52021) 是一种萜内酯，一种有效的血小板活化因子拮抗剂。Ginkgolide B 通过激活 PXR 保护内皮细胞免受外源性和内生性物质引起的损伤。Ginkgolide B 可透过脑血屏障。Ginkgolide B 具有抗氧化、抗炎、抗肿瘤和抗凋亡活性。Ginkgolide B 对缺血引起的损伤具有显着的神经保护作
远志皂苷B
Onjisaponin B 是一种从远志中发现的具有口服活性的天然产物。Onjisaponin B 能够抑制 NF-κB p65。Onjisaponin B 能够增强自噬 (autophagy)，加速突变型 α-突触核蛋白和亨廷顿蛋白的降解。Onjisaponin B 能够减少 β-淀粉样蛋白 (Aβ) 的生成。Onjisaponin B 能够减轻辐射诱导的细胞凋亡 (apoptosis)。Onjisaponin B 具有抗氧化和抗炎活性。Onjisaponin B 可用于神经系统疾病和放射损伤研究，其代谢物远志素 (TF) 能够穿透血脑屏障进入脑组织。
胡黄连苷II (标准品)
Picroside II (Standard) 是 Picroside II 的分析标准品。本产品用于研究及分析应用。Picroside II 胡黄连苷 II 是从胡黄连提取的环烯醚萜类化合物，具有抗炎和抗细胞凋亡的作用。
Picroside II 胡黄连苷 II 通过抑制 NLRP3 炎性体和 NF-κB 通路的激活，减轻脓毒症的炎症反应。
Picroside II 胡黄连苷 II 是一种抗氧化剂，可以减少 ROS 产生和保护 (CI/R) 损伤后的血脑屏障 (BBB)，具有神经保护作用。Picroside II 具有抗氧化，抗炎，免疫调节，抗病毒和其他药理活性。
(Z)-远志皂苷B
(Z)-Onjisaponin B ((Z)-Senegin III) 是 Onjisaponin B (HY-N2099) 的一种衍生物。Onjisaponin B 是一种从远志中发现的具有口服活性的天然产物。Onjisaponin B 能够抑制 NF-κB p65。Onjisaponin B 能够增强自噬 (autophagy)，加速突变型 α-突触核蛋白和亨廷顿蛋白的降解。Onjisaponin B 能够减少 β-淀粉样蛋白 (Aβ) 的生成。Onjisaponin B 能够减轻辐射诱导的细胞凋亡 (apoptosis)。Onjisaponin B 具有抗氧化和抗炎活性。Onjisaponin B 可用于神经系统疾病和放射损伤研究，其代谢物远志素 (TF) 能够穿透血脑屏障进入脑组织。
Hydralazine 是一种口服有效、可透过血脑屏障的 DNA 甲基转移酶抑制剂，具有血管舒张、松弛动脉平滑肌、降血压的活性。Hydralazine 能通过介导 DNA 去甲基化重新激活沉默的抑癌基因，同时发挥神经保护和抗炎特性。Hydralazine 可抑制 NOS-2(iNOS) 和 COX-2，减少 NO 和 PGEE2的生成；同时，清除活性氧、抑制巨噬细胞活化。Hydralazine 能够减轻运动功能障碍、神经性炎性疼痛以及福尔马林诱导的躯体和情绪性疼痛反应。此外，Hydralazine 可直接诱导 DNA 断裂和姐妹染色单体交换，表现出一定的诱变剂特征。Hydralazine 已被广泛应用于高血压、多种癌症 (如宫颈癌、白血病)、脊髓损伤及炎性疼痛机制的研究中。
通关藤苷H
Tenacissoside H (Tenacissimoside C) 是一种被发现存在于通关藤中的中药单体。Tenacissoside H 具有抗炎、抗肿瘤和神经保护作用。Tenacissoside H 可抑制 PI3K/Akt 和 NF-κB 信号通路。Tenacissoside H 可抑制癌细胞增殖、诱导细胞 S 期阻滞，并抑制小鼠体内肿瘤生长。Tenacissoside H 可通过抑制炎症和细胞凋亡 (apoptosis) 促进小鼠缺血再灌注损伤后的神经功能恢复。Tenacissoside H 可用于癌症、炎症及神经系统疾病的相关研究，如食管癌和脑缺血。
神经肽是神经元通过调节分泌途径产生和释放的小蛋白物质，在神经元中表达并具有递质或共递质功能，并作用于神经底物。神经肽是迄今为止大脑中最大和最多样化的信号分子，与疾病的发生和药物的开发息息相关。神经肽参与到炎症和免疫类疾病的发生，并对上皮细胞、血管细胞和结缔组织细胞的增殖和组织修复产生影响。已有研究表明，神经肽在神经系统受到挑战（如压力、损伤或滥用药物）时具有特别重要的作用。Substance P 是一种神经肽，在中枢神经系统中作为神经递质和神经调节剂，目前处于临床研究阶段，被证明与炎症过程和疼痛有关。
银杏内酯 B
Ginkgolide B (BN-52021) 是一种萜内酯，一种有效的血小板活化因子拮抗剂。Ginkgolide B 通过激活 PXR 保护内皮细胞免受外源性和内生性物质引起的损伤。Ginkgolide B 可透过脑血屏障。Ginkgolide B 具有抗氧化、抗炎、抗肿瘤和抗凋亡活性。Ginkgolide B 对缺血引起的损伤具有显着的神经保护作用。
远志皂苷B
Onjisaponin B 是一种从远志中发现的具有口服活性的天然产物。Onjisaponin B 能够抑制 NF-κB p65。Onjisaponin B 能够增强自噬 (autophagy)，加速突变型 α-突触核蛋白和亨廷顿蛋白的降解。Onjisaponin B 能够减少 β-淀粉样蛋白 (Aβ) 的生成。Onjisaponin B 能够减轻辐射诱导的细胞凋亡 (apoptosis)。Onjisaponin B 具有抗氧化和抗炎活性。Onjisaponin B 可用于神经系统疾病和放射损伤研究，其代谢物远志素 (TF) 能够穿透血脑屏障进入脑组织。
寡霉素 B
Oligomycin B 是一种抗生素 (antibiotic)，可作为 ATP 合酶 (ATP Synthase) 的非选择性抑制剂。Oligomycin B 可升高线粒体膜电位。Oligomycin B 诱导细胞凋亡 (apoptosis) 和坏死。Oligomycin B 会削弱葡萄霜霉菌游动孢子的运动能力并诱导其裂解。Oligomycin B 抑制小麦稻瘟病菌，并抑制小麦瘟病的发生。Oligomycin B 可降低灰葡萄孢菌的菌丝生长与孢子萌发水平，保护拟南芥抵御灰葡萄孢菌的侵害。Oligomycin B 会加重大脑皮质挫伤大鼠的脑细胞毒性水肿，升高颅内压与脑含水量，并加剧其线粒体损伤。Oligomycin B 可用于葡萄霜霉病、创伤性脑损伤、小麦瘟病、灰霉病的相关研究。
刺五加皂苷 B
Ciwujianoside B 是一种具有口服活性且可穿透血脑屏障的辐射防护剂和记忆增强剂。Ciwujianoside B 减少辐射诱导的 DNA 损伤、细胞周期阻滞和凋亡 (apoptosis)、下调 NF-κB 和 Bax/Bcl-2 比值，增强骨髓细胞增殖能力。Ciwujianoside B 可增强正常小鼠的物体识别记忆，并诱导原代培养皮质神经元的树突延伸。Ciwujianoside B 可用于造血系统辐射损伤和记忆增强相关研究。
通关藤苷H
Tenacissoside H (Tenacissimoside C) 是一种被发现存在于通关藤中的中药单体。Tenacissoside H 具有抗炎、抗肿瘤和神经保护作用。Tenacissoside H 可抑制 PI3K/Akt 和 NF-κB 信号通路。Tenacissoside H 可抑制癌细胞增殖、诱导细胞 S 期阻滞，并抑制小鼠体内肿瘤生长。Tenacissoside H 可通过抑制炎症和细胞凋亡 (apoptosis) 促进小鼠缺血再灌注损伤后的神经功能恢复。Tenacissoside H 可用于癌症、炎症及神经系统疾病的相关研究，如食管癌和脑缺血。
银杏内酯 B (标准品)
Ginkgolide B (Standard)是 Ginkgolide B 的分析标准品。本产品用于研究及分析应用。Ginkgolide B (BN-52021) 是一种萜内酯，一种有效的血小板活化因子拮抗剂。Ginkgolide B 通过激活 PXR 保护内皮细胞免受外源性和内生性物质引起的损伤。Ginkgolide B 可透过脑血屏障。Ginkgolide B 具有抗氧化、抗炎、抗肿瘤和抗凋亡活性。Ginkgolide B 对缺血引起的损伤具有显着的神经保护作
胡黄连苷II (标准品)
Picroside II (Standard) 是 Picroside II 的分析标准品。本产品用于研究及分析应用。Picroside II 胡黄连苷 II 是从胡黄连提取的环烯醚萜类化合物，具有抗炎和抗细胞凋亡的作用。
Picroside II 胡黄连苷 II 通过抑制 NLRP3 炎性体和 NF-κB 通路的激活，减轻脓毒症的炎症反应。
Picroside II 胡黄连苷 II 是一种抗氧化剂，可以减少 ROS 产生和保护 (CI/R) 损伤后的血脑屏障 (BBB)，具有神经保护作用。Picroside II 具有抗氧化，抗炎，免疫调节，抗病毒和其他药理活性。
(Z)-远志皂苷B
(Z)-Onjisaponin B ((Z)-Senegin III) 是 Onjisaponin B (HY-N2099) 的一种衍生物。Onjisaponin B 是一种从远志中发现的具有口服活性的天然产物。Onjisaponin B 能够抑制 NF-κB p65。Onjisaponin B 能够增强自噬 (autophagy)，加速突变型 α-突触核蛋白和亨廷顿蛋白的降解。Onjisaponin B 能够减少 β-淀粉样蛋白 (Aβ) 的生成。Onjisaponin B 能够减轻辐射诱导的细胞凋亡 (apoptosis)。Onjisaponin B 具有抗氧化和抗炎活性。Onjisaponin B 可用于神经系统疾病和放射损伤研究，其代谢物远志素 (TF) 能够穿透血脑屏障进入脑组织。
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
MedchemExpress Validation 03
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
MedchemExpress Validation 04
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
